Organocatalytic asymmetric total synthesis of (R)-Rolipram and formal synthesis of (3S,4R)-Paroxetine

被引：130

作者：

Hynes, Peter S. ^{[1
]}

Stupple, Paul A. ^{[2
]}

Dixon, Darren J. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[2] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 07期

关键词：

D O I：

10.1021/ol800108u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient enantioselective total synthesis of (R)-rolipram and an efficient enantioselective formal synthesis of (3S,4R)-paroxetine has been achieved using the highly enantioselective Michael addition of malonate nucleophiles as key steps in both cases.

引用

页码：1389 / 1391

页数：3

共 55 条

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