Organocatalytic asymmetric total synthesis of (R)-Rolipram and formal synthesis of (3S,4R)-Paroxetine

被引:130
作者
Hynes, Peter S. [1 ]
Stupple, Paul A. [2 ]
Dixon, Darren J. [1 ]
机构
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
[2] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England
关键词
D O I
10.1021/ol800108u
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient enantioselective total synthesis of (R)-rolipram and an efficient enantioselective formal synthesis of (3S,4R)-paroxetine has been achieved using the highly enantioselective Michael addition of malonate nucleophiles as key steps in both cases.
引用
收藏
页码:1389 / 1391
页数:3
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