Intramolecular amination catalysed by ruthenium and palladium. Synthesis of 2-acyl indoles and 2-aryl quinolines by carbonylation of 2-nitrochalcones

被引：25

作者：

Cenini, S ^{[1
]}

Bettettini, E ^{[1
]}

Fedele, M ^{[1
]}

Tollari, S ^{[1
]}

机构：

[1] CTR CNR,I-20133 MILAN,ITALY

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 1996年 / 111卷 / 1-2期

关键词：

amination; carbonylation; palladium; ruthenium; 2-acyl indoles; 2-arylquinolines;

D O I：

10.1016/1381-1169(96)00123-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The carbonylation in toluene of 2-nitrochalcones at 20 bar and 100 degrees C, with Pd(TMB)(2) as catalyst and TMPhen as cocatalyst (TMBH = 2,4,6-trimethyl benzoic acid; TMPhen = 3,4,7,8-tetramethyl-1,10-phenanthroline) gave the corresponding 2-acyl indoles in 60-98% yields. The use as catalyst of Ru-3(CO)(12) activated by a rigid alpha-diimine ligand such as DIAN-Me((*)), in ethanol-water, at 30 bar and 170 degrees C, gave a mixture of the corresponding acyl indoles and quinolines, the latter being usually the most abundant products.

引用

页码：37 / 41

页数：5

共 22 条

[1] TRANSITION-METAL COMPLEX-CATALYZED REDUCTIVE N-HETEROCYCLIZATION - SYNTHESIS OF 4(3H)-QUINAZOLINONE DERIVATIVES FROM N-(2-NITROBENZOYL)AMIDES [J].