An endophytic Neurospora sp from Nothapodytes foetida producing camptothecin

被引：70

作者：

Rehman, S. ^{[1
]}

Shawl, A. S. ^{[1
]}

Kour, A. ^{[1
]}

Andrabi, R. ^{[2
]}

Sudan, P. ^{[2
]}

Sultan, P. ^{[1
]}

Verma, V. ^{[2
]}

Qazi, G. N. ^{[2
]}

机构：

[1] Reg Res Lab, Sanat Nagar Srinagar 190005, India

[2] Reg Res Lab, Jammu 180001, India

来源：

APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2008年 / 44卷 / 02期

关键词：

D O I：

10.1134/S0003683808020130

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The medicinal plant, Nothapodytes foetida, contains a number of important alkaloids like camptothecin (an anticancer drug molecule), but its concentration is less to meet the existing demand of this important molecule, in an effort for accessible availability of camptothecin. An endophyte (designated ZP5SE) was isolated from the seed of Nothapodytes foetida and was examined as a potential source of anticancer drug lead compound, i.e., camptothecin, when grown in Sabouraud liquid culture media under shake flask conditions. The presence of an anticancer compound (camptothecin) in this fungus was confirmed by chromatographic and spectroscopic methods in comparison with authentic camptothecin. Isolated endophyte (Neurospora crassa) producing camptothecin may become an easily accessible source for the production of a precursor anticancer drug molecule in the future at a large scale.

引用

页码：203 / 209

页数：7

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