Hyaluronan biofilms reinforced with partially deacetylated chitin nanowhiskers: Extraction, fabrication, in-vitro and antibacterial properties of advanced nanocomposites

被引：25

作者：

Abdelrahman, R. M. ^{[1
]}

Abdel-Mohsen, A. M. ^{[1
,2
,3
]}

Zboncak, M. ^{[1
]}

Frankova, J. ^{[4
]}

Lepcio, P. ^{[1
]}

Kobera, L. ^{[5
]}

Steinhart, M. ^{[5
]}

Pavlinak, D. ^{[6
]}

Spotaz, Z. ^{[1
]}

Sklenareva, R. ^{[4
]}

Brus, J. ^{[5
]}

Jancar, J. ^{[1
,2
,7
]}

机构：

[1] Brno Univ Technol, CEITEC Cent European Inst Technol, Purkynova 656-123, Brno 61200, Czech Republic

[2] SCITEG As, Brno, Czech Republic

[3] Natl Res Ctr, Dept Pretreatment & Finishing Cellulos Based Text, Text Ind Res Div, 33 Buhouth St, Giza 12622, Egypt

[4] Palacky Univ Olomouc, Fac Med & Dent, Dept Med Chem & Biochem, Olomouc, Czech Republic

[5] Czech Acad Sci, Inst Macromol Chem, Heyrovskeho Nam 2, Prague 16206 6, Czech Republic

[6] Masaryk Univ, Dept Phys Elect, Kotlarska 267-2, CS-61137 Brno, Czech Republic

[7] Brno Univ Technol, Inst Mat Chem, Facil Chem, Purkynova 464-118, Brno 61200, Czech Republic

来源：

CARBOHYDRATE POLYMERS | 2020年 / 235卷

关键词：

Nanocomposite biofilm; Hyaluronan; Nanowhiskers; Cytotoxicity; Bactericidal activity; ALPHA-CHITIN; CHITOSAN; ACID; BIOCOMPATIBILITY; NANOPARTICLES; HYDROLYSIS; HYDROGEL; COMPLEX; FIBERS; LENGTH;

D O I：

10.1016/j.carbpol.2020.115951

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Fabrication of nanocomposite biofilms with enhanced mechanical and antibacterial properties was successfully achieved from hyaluronan (HA) and partially deacetylated chitin nanowhiskers (ChNWs) by a casting-evaporation method. The hydrolysis process of chitin showed an important role in the dimensions, stability, and the crystallinity of extracted ChNWs in a time-dependent manner. The volume fraction of ChNWs nanofiller varying from (0.001 to 0.5) exhibited a great influence on the mechanical properties of the biofilms (young modulus, strength) was enhanced by the high load-bearing capacity of NWs compared with net HA film. The antibacterial activity of the nanocomposite biofilms exhibited significant bactericidal activity against different types of bacteria (- / + gram). HA/ChNWs Nanocomposite biofilms did not show any toxicity against normal human dermal fibroblasts (NHDF) and human primary osteogenic sarcoma (Saos-2) cell lines. The new biofilms with unique properties like edibleness, environmental friendliness, high mechanical properties, antibacterial performance, and non-cytotoxicity that could be used in skin tissue regenerations, and drug delivery applications.

引用

页数：13

共 46 条

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