Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors

被引：11

作者：

Chen, Yen Ting ^{[1
]}

Vojkovsky, Tomas ^{[1
]}

Fang, Xingang ^{[1
]}

Pocas, Jennifer R. ^{[1
]}

Grant, Wayne ^{[1
]}

Handy, Amiee M. W. ^{[1
]}

Schroeter, Thomas ^{[1
]}

LoGrasso, Philip ^{[1
]}

Bannister, Thomas D. ^{[1
]}

Fang, Yangbo ^{[1
]}

机构：

[1] Scripps Florida, Translat Res Inst, Jupiter, FL 33458 USA

来源：

MEDCHEMCOMM | 2011年 / 2卷 / 01期

关键词：

D O I：

10.1039/c0md00194e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rho kinase (ROCK) is currently investigated as a target for various diseases such as glaucoma and spinal cord injury. Herein, we report the asymmetric synthesis of chroman 1, a highly potent ROCK inhibitor, and its analogs. The inhibitory properties of these compounds for ROCK-II and a selected set of highly homologous kinases are also discussed.

引用

页码：73 / 75

页数：3

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