CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system

被引：52

作者：

Hubert, George W. ^{[1
]}

Jones, Douglas C. ^{[1
]}

Moffett, Mark C. ^{[1
]}

Rogge, George ^{[1
]}

Kuhar, Michael J. ^{[1
]}

机构：

[1] Emory Univ, Yerkes Natl Primate Res Ctr, Div Neurosci, Atlanta, GA 30329 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2008年 / 75卷 / 01期

关键词：

drug addiction; cocaine; amphetamine; nucleus accumbens; CART;

D O I：

10.1016/j.bcp.2007.07.028

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cocaine- and amphetamine-regulated transcript (CART) peptides (CART 55-102 and CART 62-102) are peptidergic neurotransmitters that are widely but specifically distributed throughout the brain, gut and other parts of the body. They are found in many brain regions associated with drug addiction including the nucleus accumbens, ventral tegmental area and ventral pallidum. Injections of CART 55-102 into the nucleus accumbens have no effect on basal locomotor activity. However, an injection of CART just before an i.p. injection of cocaine reduces the locomotor activating effects of cocaine. These and other data suggest that CART in the accumbens blunts the effects of cocaine. A hypothesis is that CART is homeostatic in the accumbens and tends to oppose large increases in dopamine signaling. These actions would therefore be able to regulate the effects of some abused drugs such as the psychostimulants. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：57 / 62

页数：6

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