Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones

被引：12

作者：

Ahn, Gang ^{[1
]}

Schifano-Faux, Nadege ^{[2
]}

Goossens, Jean-Francois ^{[2
]}

Baldeyrou, Brigitte ^{[3
,4
]}

Couture, Axel ^{[1
]}

Grandclaudon, Pierre ^{[1
,5
]}

Lansiaux, Amelie ^{[3
,4
]}

Ryckebusch, Adina ^{[1
,5
]}

机构：

[1] Univ Lille 1, EA CMF 4478, F-59655 Villeneuve Dascq, France

[2] Univ Lille 2, EA 4481, Chim Analyt Lab, F-59006 Lille, France

[3] Univ Lille 2, Ctr Oscar Lambret, Inserm U837, IRCL, F-59045 Lille, France

[4] IMPRT, F-59045 Lille, France

[5] Ecole Natl Super Chim, F-59652 Villeneuve Dascq, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 08期

关键词：

Cancer; DNA intercalators; Topoisomerases; Indenoisoquinolines; I INHIBITORS; NITRATED INDENOISOQUINOLINES; ANTIPROLIFERATIVE EVALUATION; DNA INTERACTION; DERIVATIVES; RESISTANCE; OPTIMIZATION; ANHYDRIDES; ASSAYS;

D O I：

10.1016/j.bmcl.2011.02.106

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of mono-or diaminoalkylated indeno[1,2-c]isoquinolin-5,11-diones analogs of 1 were synthesized and evaluated for their DNA binding affinities, topoisomerase inhibition properties and antiproliferative activities against human cancer cell lines (HL60). Impact of the side chain connected to the aromatic D ring and to the N6 lactam position on the biological profile will be discussed. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2259 / 2263

页数：5

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