The brain network reflecting bodily self-consciousness: a functional connectivity study

被引:72
作者
Ionta, Silvio [1 ,2 ]
Martuzzi, Roberto [1 ,2 ]
Salomon, Roy [1 ,2 ]
Blanke, Olaf [1 ,2 ,3 ]
机构
[1] Ecole Polytech Fed Lausanne, Sch Life Sci, Ctr Neuroprosthet, CH-1015 Lausanne, Switzerland
[2] Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Cognit Neurosci, CH-1015 Lausanne, Switzerland
[3] Univ Hosp, Dept Neurol, CH-1211 Geneva, Switzerland
基金
瑞士国家科学基金会;
关键词
self-location; first-person perspective; temporoparietal junction; insula; multisensory integration; RUBBER HAND ILLUSION; RESTING-STATE NETWORKS; PARIETAL CORTEX; RIGHT-HEMISPHERE; BODY OWNERSHIP; TEMPOROPARIETAL JUNCTION; MULTISENSORY MECHANISMS; PERSPECTIVE-TAKING; BAND OSCILLATIONS; SPATIAL NEGLECT;
D O I
10.1093/scan/nst185
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Several brain regions are important for processing self-location and first-person perspective, two important aspects of bodily self-consciousness. However, the interplay between these regions has not been clarified. In addition, while self-location and first-person perspective in healthy subjects are associated with bilateral activity in temporoparietal junction (TPJ), disturbed self-location and first-person perspective result from damage of only the right TPJ. Identifying the involved brain network and understanding the role of hemispheric specializations in encoding self-location and first-person perspective, will provide important information on system-level interactions neurally mediating bodily self-consciousness. Here, we used functional connectivity and showed that right and left TPJ are bilaterally connected to supplementary motor area, ventral premotor cortex, insula, intraparietal sulcus and occipitotemporal cortex. Furthermore, the functional connectivity between right TPJ and right insula had the highest selectivity for changes in self-location and first-person perspective. Finally, functional connectivity revealed hemispheric differences showing that self-location and first-person perspective modulated the connectivity between right TPJ, right posterior insula, and right supplementary motor area, and between left TPJ and right anterior insula. The present data extend previous evidence on healthy populations and clinical observations in neurological deficits, supporting a bilateral, but right-hemispheric dominant, network for bodily self-consciousness.
引用
收藏
页码:1904 / 1913
页数:10
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