Development of a sensor device with polymer-coated piezoelectric micro-cantilevers for detection of volatile organic compounds

被引:8
作者
Ahmed, Waqar M. [1 ]
Steenwelle, Ruud J. A. [2 ]
Knobel, Hugo H. [3 ]
Davie, Alan [4 ]
Steijvers, Ron [4 ]
Verhoeckx, Fred [4 ]
Goodacre, Royston [5 ]
Fowler, Stephen J. [1 ,6 ]
Rijnders, A. J. H. M. [2 ]
Nijsen, Tamara M. [4 ]
机构
[1] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Manchester, Lancs, England
[2] Univ Twente, Fac Sci & Technol, Enschede, Netherlands
[3] Eurofins Mat Sci Netherlands BV, Eindhoven, Netherlands
[4] Royal Philips BV, Philips Res, Eindhoven, Netherlands
[5] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England
[6] Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Wythenshawe, England
基金
欧盟第七框架计划;
关键词
volatile organic compounds; sensor; cantilever; breathdx; BREATH ANALYSIS; METABOLOMICS; THRESHOLD; DIAGNOSIS; TUBE; MS;
D O I
10.1088/1361-6501/ab4f2f
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Exhaled breath contains thousands of volatile organic compounds (VOCs), some of which have been associated with respiratory disease. We describe a sensor device with an array of eight polymer-coated piezoelectric micro-cantilevers (two of each polyacrylic acid, polyethylenimine and polyethylene glycol and two uncoated cantilevers) and an electronic resonant frequency readout, designed for analysis of VOCs. We have measured the system's response to temperature (24 degrees C to 40 degrees C), pressure (200 mmHg to 760 mmHg), and humidity (10% to 50% RH), evaluated the reproducibility of measurements between micro-cantilevers (n = 3), and tested the stability of the system over six months. By measuring the frequency shift of the resonating micro-cantilevers, and using the inflection point of a fitted sigmoid model, we show that acetone, ethanol, octane are distinguishable from one another, with a measurement limited of detection of 1568, 383, and 87 ppmv, respectively. From interpolation of the electronic readout, we found the lowest estimated measurement to be 5 ppmv (acetone on polyacrylic acid). We have also shown that polar mixture (acetone, ethanol, and water) and non- polar mixture (increasing octane concentration and decreasing polar mixture constituents) can be differentiated.
引用
收藏
页数:11
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