Inhibition of aldehyde dehydrogenase by furazolidone nanoemulsion to decrease cisplatin resistance in lung cancer cells

被引：6
作者：
Darooee, Mina [1 ]
Akbari, Vajihe [2 ,3 ]
Taheri, Azade [1 ]
机构：
[1] Isfahan Univ Med Sci, Fac Pharm, Dept Pharmaceut, Novel Drug Delivery Syst Res Ctr, Esfahan, Iran
[2] Isfahan Univ Med Sci, Fac Pharm, Dept Pharmaceut Biotechnol, Esfahan, Iran
[3] Isfahan Univ Med Sci, Fac Pharm, Isfahan Pharmaceut Res Ctr, Esfahan, Iran
来源：
THERAPEUTIC DELIVERY | 2021年 / 12卷 / 08期
关键词：
aldehyde dehydrogenase; cisplatin; Furazolidone; nanoemulsion; sensitivity; SOLID LIPID NANOPARTICLES; BREAST-CANCER; DRUG-DELIVERY; 1A1; ALDH1A1; BIOAVAILABILITY; EXPRESSION; DESIGN; POLOXAMINE-908; POLOXAMER-407; CHEMOTHERAPY;
D O I：
10.4155/tde-2020-0130
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The overexpression of aldehyde dehydrogenase (ALDH) in cancer cells contributes to therapeutic resistance. Furazolidone (FUR) is a strong ALDH inhibitor. Methods: FUR nanoemulsion (NE) was formulated and tested for ALDH inhibitory activity in comparison with free FUR. The cytotoxic potential of cisplatin was evaluated in combination with free FUR and FUR NE. Results: The optimized FUR NE showed droplet size of 167.9 +/- 3.1 nm and drug content of 84.2 +/- 2.3%. FUR NE inhibited 99.75 +/- 2.1% of ALDH activity while 25.0 +/- 4.6% was inhibited by free FUR. FUR NE increased the sensitivity to cisplatin in A549 cells by more than tenfold by its ALDH inhibitory effects. Conclusion: This finding can be a promising approach to improve cancer survival in ALDH-positive drug-resistant cancers.
引用
收藏
页码：611 / 625
页数：15
相关论文
共 75 条
[1]   Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion [J].
Abdou, Ebtsam M. ;
Kandil, Soha M. ;
El Miniawy, Hala M. F. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 529 (1-2) :667-677
[2]   The design of naproxen solid lipid nanoparticles to target skin layers [J].
Akbari, Jafar ;
Saeedi, Majid ;
Morteza-Semnani, Katayoun ;
Rostamkalaei, Seyyed Sohrab ;
Asadi, Masoumeh ;
Asare-Addo, Kofi ;
Nokhodchi, Ali .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 145 :626-633
[3]   Formulation and advantages of furazolidone in liposomal drug delivery systems [J].
Alam, Muhammad Irfan ;
Paget, Timothy ;
Elkordy, Amal Ali .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 84 :139-145
[4]   The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer [J].
Alamgeer, Muhammad ;
Ganju, Vinod ;
Szczepny, Anette ;
Russell, Prudence A. ;
Prodanovic, Zdenka ;
Kumar, Beena ;
Wainer, Zoe ;
Brown, Tracey ;
Schneider-Kolsky, Michal ;
Conron, Matthew ;
Wright, Gavin ;
Watkins, D. Neil .
THORAX, 2013, 68 (12) :1095-1104
[5]   Development and characterization of parenteral nanoemulsions containing thalidomide [J].
Araujo, F. A. ;
Kelmann, R. G. ;
Araujo, B. V. ;
Finatto, R. B. ;
Teixeira, H. F. ;
Koester, L. S. .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 42 (03) :238-245
[6]   RAPID PURIFICATION AND PROPERTIES OF POTASSIUM-ACTIVATED ALDEHYDE DEHYDROGENASE FROM SACCHAROMYCES-CEREVISIAE [J].
BOSTIAN, KA ;
BETTS, GF .
BIOCHEMICAL JOURNAL, 1978, 173 (03) :773-786
[7]   Preparation and optimization of PIT solid lipid nanoparticles via statistical factorial design [J].
Carbone, C. ;
Tomasello, B. ;
Ruozi, B. ;
Renis, M. ;
Puglisi, G. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 49 :110-117
[8]   Identification of the enzymatic mechanism of nitroglycerin bioactivation [J].
Chen, ZQ ;
Zhang, J ;
Stamler, JS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8306-8311
[9]   Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform [J].
Choudhury, Hira ;
Gorain, Bapi ;
Karmakar, Sanmoy ;
Biswas, Easha ;
Dey, Goutam ;
Barik, Rajib ;
Mandal, Mahitosh ;
Pal, Tapan Kumar .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2014, 460 (1-2) :131-143
[10]  
Craig D.Q. M., 2006, Thermal Analysis of Pharmaceuticals
12345678