Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity

被引：48

作者：

Steyger, Peter S. ^{[1
,2
]}

机构：

[1] Creighton Univ, Translat Hearing Ctr, Omaha, NE 68178 USA

[2] VA Portland Hlth Care Syst, Natl Ctr Rehabil Auditory Res, Portland, OR 97239 USA

来源：

AMERICAN JOURNAL OF AUDIOLOGY | 2021年 / 30卷 / 3S期

关键词：

SENSORINEURAL HEARING-LOSS; OUTER HAIR-CELLS; PLATINUM-INDUCED OTOTOXICITY; D-METHIONINE PROTECTS; RISK-FACTORS; GENTAMICIN OTOTOXICITY; GUINEA-PIG; INDUCED NEUROTOXICITY; SCREENING OUTCOMES; AUDITORY FUNCTION;

D O I：

10.1044/2021_AJA-21-00006

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Purpose: This review article summarizes our current understanding of the mechanisms underlying acquired hearing loss from hospital-prescribed medications that affects as many as 1 million people each year in Western Europe and North America. Yet, there are currently no federally approved drugs to prevent or treat the debilitating and permanent hearing loss caused by the life-saving platinum-based anticancer drugs or the bactericidal aminoglycoside antibiotics. Hearing loss has long-term impacts on quality-of-life measures, especially in young children and older adults. This review article also highlights some of the current knowledge gaps regarding iatrogenic causes of hearing loss. Conclusion: Further research is urgently needed to further refine clinical practice and better ameliorate iatrogenic drug-induced hearing loss.

引用

页码：887 / 900

页数：14

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