Effects of Vitamin D on Systemic Lupus Erythematosus Disease Activity and Autoimmunity: A Systematic Review and Meta-Analysis

被引：8

作者：

Irfan, Shayan A. ^{[1
]}

Ali, Abid A. ^{[1
]}

Shabbir, Naqiha ^{[1
]}

Altaf, Hina ^{[2
]}

Ahmed, Ali ^{[1
]}

Kunnath, Jafrikh Thamara ^{[3
]}

Boorle, Naga Vijaya L. Divya ^{[4
]}

Miguel, April K. ^{[5
]}

Loh, Chia Chi ^{[6
]}

Gandrakota, Nikhila ^{[7
]}

Baig, Mirza M. Ali ^{[1
]}

机构：

[1] Dow Univ Hlth Sci, Internal Med, Karachi, Pakistan

[2] Dr Ruth KM Pfau Civil Hosp Karachi, Dow Med Coll, Karachi, Pakistan

[3] Govt Med Coll, Internal Med, Kozhikode, India

[4] Wayne State Univ, Internal Med, Detroit, MI USA

[5] Univ City Manila, Internal Med, Manila, Philippines

[6] Manipal Univ Coll Malaysia, Internal Med, Melaka, Malaysia

[7] Emory Univ, Sch Med, Family Med, Atlanta, GA USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 06期

关键词：

sle; anti-dsdna; sledai; vitamin d; systemic lupus erythematosus; ASSOCIATION; FATIGUE;

D O I：

10.7759/cureus.25896

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aims to assess the role of vitamin D on systemic lupus erythematosus (SLE) patients and its effects on systemic lupus erythematosus disease activity index (SLEDAI), anti-double-stranded DNA (anti-dsDNA), C3, C4, and fatigue in patients with SLE. A systemic search was conducted using three electronic databases, i.e., PubMed/Medline, Cochrane Library, and Google Scholar. Review Manager 5.4.1 (The Cochrane Collaboration, The Nordic Cochrane Centre, Copenhagen, Denmark) was employed for statistical analysis. All studies meeting the inclusion criteria were selected. A random-effect model was used to pool the studies, and the result was reported in the standard mean difference (SMD) with its corresponding 95% confidence interval. Six randomized controlled trials were selected. Five outcomes were assessed (SLEDAI, anti-dsDNA, C3, C4, and fatigue) to evaluate the role of vitamin D in SLE patients. A significant decrease in SLEDAI (SMD = -0.85 (-1.12, -0.58); p < 0.00001; I-2 = 42%) and a non-significant decrease in anti-dsDNA (SMD = -0.09 (-0.03, 0.12); p = 0.42; I-2 = 0%) was noted. A significant increase in levels of C3 (SMD = 0.30 (0.09, 0.51); p = 0.006; I-2 = 0%) and fatigue (SMD = -1.27 (-2.38, -0.16); p = 0.02; I-2 = 56%) was noted when vitamin D was used. Insignificant difference was observed in C4 (SMD = 0.20 (-0.02, 0.41); p = 0.07; I2 = 0%). Vitamin D in SLE patients showed a significant decrease in SLEDAI scores and a significant increase in C3 levels. The effect of vitamin D on fatigue was inconclusive. No significant difference in anti-dsDNA and C4 levels was noted.

引用

页数：11

共 37 条

[31] Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation [J].