Osteonecrosis in children with acute lymphoblastic leukemia: A report from Children's Cancer Hospital Egypt (CCHE)

被引:8
作者
Ali, Nesreen [1 ,2 ]
Gohar, Seham [2 ]
Zaky, Iman [3 ,4 ]
Elghoneimy, Ahmed [5 ,6 ]
Youssef, Sarah [7 ]
Sameer, Gehad [8 ]
Yassin, Dina [9 ,10 ]
Salem, Sherine [9 ,10 ]
Magdi, Hadeel [11 ]
Sidhom, Iman [1 ,2 ]
机构
[1] Cairo Univ, NCI, Pediat Oncol & Hematol, CCHE57357,Sect 7,Bldg 18-39, Giza, Egypt
[2] Children Canc Hosp, Pediat Oncol & Hematol, CCHE57357,Sect 7,Bldg 18-39, Cairo, Egypt
[3] Cairo Univ, NCI, Radiodiag, Giza, Egypt
[4] Children Canc Hosp, Radiodiag, Cairo, Egypt
[5] Cairo Univ, Orthoped Surg, Kasr Eeiny, Giza, Egypt
[6] Children Canc Hosp, Orthoped Surg, Cairo, Egypt
[7] Children Canc Hosp, Board Certified Oncol Pharmacist, Cairo, Egypt
[8] Children Canc Hosp, Clin Pharm, Cairo, Egypt
[9] Cairo Univ, NCI, Clin Pathol, Giza, Egypt
[10] Children Canc Hosp, Clin Pathol, Cairo, Egypt
[11] Children Canc Hosp, Clin Res, Cairo, Egypt
关键词
acute lymphoblastic leukemia; childhood; dexamethasone; osteonecrosis; RISK-FACTORS; SYMPTOMATIC OSTEONECROSIS; PEDIATRIC-PATIENTS; CHILDHOOD-CANCER; DEXAMETHASONE; ADOLESCENTS; ASPARAGINASE; SURVIVORS; THERAPY; COHORT;
D O I
10.1002/pbc.27440
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background As survival rates for children with acute lymphoblastic leukemia (ALL) improve, awareness of treatment complications becomes important. Osteonecrosis (ON) is a serious disabling complication in treated ALL patients. The aim of the study was to define the frequency of ON identified by magnetic resonance imaging (MRI) and to study the risk factors for ON. Patients and methods Results The frequency of ON was evaluated retrospectively in 858 patients with ALL who were diagnosed at Children's Cancer Hospital of Egypt from January 2009 to December 2012. Patients were treated with St Jude Total Therapy Study XV. Of 858 patients evaluated, 665 were eligible for the study and 65 (9.7%) developed ON. The cumulative 5-year incidence of ON was 11.96% (SE, 0.131%). Of 154 patients aged 10 years and older, 40 (26%) developed ON. The mean age of patients with ON was 10.7 years. The prognostic factors with a significant relationship with ON were age 10 years and older (P = 0.0001) and intermediate-/high-risk group (P = 0.0001). However, gender did not have a significant relationship. At the onset of ON, the mean cumulative dexamethasone dose was 796 mg/m(2), and the mean total corticosteroid dose, calculated as prednisolone equivalence, was 6,431 mg/m(2). Out of 43 patients who developed ON while on corticosteroid therapy, 36 (84%) required dexamethasone dose modification and/or discontinuation. Conclusion The frequency of ON among the studied patients was 9.7%. Risk factors with a significant association with ON were older age and more intensive corticosteroid therapy.
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页数:7
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共 25 条
  • [1] Osteonecrosis in children and adolescents with cancer
    Barr, Ronald D.
    Sala, Alessandra
    [J]. PEDIATRIC BLOOD & CANCER, 2008, 50 (02) : 483 - 485
  • [2] Osteonecrosis:: A treatment related toxicity in childhood acute lymphoblastic leukemia (ALL) -: Experiences from trial ALL-BFM 95
    Bürger, B
    Beier, R
    Zimmermann, M
    Beck, JD
    Reiter, A
    Schrappe, M
    [J]. PEDIATRIC BLOOD & CANCER, 2005, 44 (03) : 220 - 225
  • [3] Incidence, risk factors, and treatment outcome of symptomatic osteonecrosis in Taiwanese children with acute lymphoblastic leukemia: a retrospective cohort study of 245 patients in a single institution
    Chen, Shih-Hsiang
    Chang, Tsung-Yen
    Jaing, Tang-Her
    Lee, Mel S.
    Wang, Chao-Jan
    Hung, Iou-Jih
    Yang, Chao-Ping
    [J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2015, 102 (01) : 41 - 47
  • [4] Osteonecrosis of the femoral head: Diagnosis and classification systems
    Choi H.-R.
    Steinberg M.E.
    Y. Cheng E.
    [J]. Current Reviews in Musculoskeletal Medicine, 2015, 8 (3) : 210 - 220
  • [5] Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood
    Girard, Pauline
    Auquier, Pascal
    Barlogis, Vincent
    Contet, Audrey
    Poiree, Maryline
    Demeocq, Francois
    Berbis, Julie
    Herrmann, Iris
    Villes, Virginie
    Sirvent, Nicolas
    Kanold, Justyna
    Chastagner, Pascal
    Chambost, Herve
    Plantaz, Dominique
    Michel, Gerard
    [J]. HAEMATOLOGICA, 2013, 98 (07) : 1089 - 1097
  • [6] Glueck CJ, 2001, CLIN ORTHOP RELAT R, P19
  • [7] Assessment of Corticosteroid-induced Osteonecrosis in Children Undergoing Chemotherapy for Acute Lymphoblastic Leukemia: A Report From the Japanese Childhood Cancer and Leukemia Study Group
    Hyakuna, Nobuyuki
    Shimomura, Yasuto
    Watanabe, Arata
    Taga, Takashi
    Kikuta, Atsushi
    Matsushita, Takeji
    Kogawa, Kazuhiro
    Kawakami, Chihiro
    Horikoshi, Yasuo
    Iwai, Tsuyako
    Okamoto, Yasuhiro
    Tsurusawa, Masahito
    Asami, Keiko
    [J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2014, 36 (01) : 22 - 29
  • [8] Osteonecrosis in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study
    Kadan-Lottick, Nina S.
    Dinu, Irina
    Wasilewski-Masker, Karen
    Kaste, Sue
    Meacham, Lillian R.
    Mahajan, Anita
    Stovall, Marilyn
    Yasui, Yutaka
    Robison, Leslie L.
    Sklar, Charles A.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (18) : 3038 - 3045
  • [9] MRI of knee osteonecrosis in children with leukemia and lymphoma: Part I, observer agreement
    Karimova, EJ
    Rai, SN
    Deng, X
    Ingle, DJ
    Ralph, AC
    Neel, MD
    Kaste, SC
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 2006, 186 (02) : 470 - 476
  • [10] Utility of Early Screening Magnetic Resonance Imaging for Extensive Hip Osteonecrosis in Pediatric Patients Treated With Glucocorticoids
    Kaste, Sue C.
    Pei, Deqing
    Cheng, Cheng
    Neel, Michael D.
    Bowman, W. Paul
    Ribeiro, Raul C.
    Metzger, Monika L.
    Bhojwani, Deepa
    Inaba, Hiroto
    Campbell, Patrick
    Rubnitz, Jeffrey E.
    Jeha, Sima
    Sandlund, John T.
    Downing, James R.
    Relling, Mary V.
    Pui, Ching-Hon
    Howard, Scott C.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (06) : 610 - U117