Gold-Catalyzed Regiospecific Hydration of N-Tosyl Propargylic Amines

被引：9

作者：

Ying, Jun ^{[1
]}

Wang, Hai ^{[1
]}

Qi, Xinxin ^{[1
]}

Peng, Jin-Bao ^{[1
]}

Wu, Xiao-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Xiasha Campus, Hangzhou 310018, Zhejiang, Peoples R China

[2] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

ORGANOMETALLICS | 2018年 / 37卷 / 17期

关键词：

REGIOSELECTIVE HYDRATION; KETONES; ALKYNES; CYCLOISOMERIZATION; DERIVATIVES; CYCLIZATION; 1,6-ENYNES; VERSATILE; STRATEGY; ESTERS;

D O I：

10.1021/acs.organomet.8b00549

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A gold-catalyzed regiospecific hydration of N-tosyl propargylic amines has been developed. In the presence of a catalytic amount of the gold catalyst NaAuCl4 center dot 2H(2)O, both alkyl and aryl-substituted N-tosyl propargylic amines were smoothly converted into the corresponding beta-amino ketones with excellent regioselectivities and high yields (up to 85%). Further transformations of the obtained beta-amino ketones to valuable 1,3-amino alcohols were demonstrated as well.

引用

页码：2837 / 2841

页数：5

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