Sweets for a Bitter End: Lung Cancer Cell-Surface Protein Glycosylation Mediates Metastatic Colonization

被引：13

作者：

Arnal-Estape, Anna ^{[1
]}

Nguyen, Don X. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Yale Canc Ctr, New Haven, CT 06520 USA

来源：

CANCER DISCOVERY | 2015年 / 5卷 / 02期

关键词：

PROGRESSION;

D O I：

10.1158/2159-8290.CD-15-0013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glycosylation is one of the most predominant forms of cell-surface protein modifications, yet its deregulation in cancer and contribution to tumor microenvironment interactions remain poorly understood. In this issue of Cancer Discovery, Reticker-Flynn and Bhatia characterize an enzymatic switch in lung cancer cells that triggers aberrant surface protein glycosylation patterns, adhesion to lectins on the surface of inflammatory cells, and subsequent metastatic colonization of the liver. (C) 2015 AACR.

引用

页码：109 / 111

页数：3

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