Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers

被引：55
作者：
Grkovic, Mirjana [1 ]
Stojanovic, Dusica B. [2 ]
Pavlovic, Vladimir B. [3 ]
Rajilic-Stojanovic, Mirjana [2 ]
Bjelovic, Milos [4 ]
Uskokovic, Petar S. [2 ]
机构：
[1] Univ Belgrade, Innovat Ctr, Fac Technol & Met, Karnegijeva 4, Belgrade 11000, Serbia
[2] Univ Belgrade, Fac Technol & Met, Karnegijeva 4, Belgrade 11000, Serbia
[3] Univ Belgrade, Fac Agr, Nemanjina 6, Belgrade 11080, Serbia
[4] Univ Belgrade, Fac Med, Dr Subotica 8, Belgrade 11000, Serbia
来源：
COMPOSITES PART B-ENGINEERING | 2017年 / 121卷
关键词：
Polymer-matrix composites (PMCs); Nano-structures; Mechanical properties; Thermal properties; CITRIC-ACID; ANTIMICROBIAL PROPERTIES; POLYETHYLENE OXIDE; NANOPARTICLES; RELEASE; DELIVERY; FIBERS; CYTOTOXICITY; FABRICATION; HYDROGELS;
D O I：
10.1016/j.compositesb.2017.03.024
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：58 / 67
页数：10
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