Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems

被引：276

作者：

Xuan, Weimin ^{[2
]}

Sheng, Chunquan ^{[1
]}

Cao, Yanting ^{[2
]}

He, Wenhan ^{[2
]}

Wang, Wei ^{[2
,3
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Med Chem, Shanghai 200433, Peoples R China

[2] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

[3] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 10期

基金：

美国国家科学基金会;

关键词：

azides; fluorescein; fluorescent probes; hydrogen sulfide; rhodamines; ION CHROMATOGRAPHY; BRAIN-TISSUE; 3RD GAS; H2S; CONSUMPTION; MEDIATOR; BLOOD; CELLS; STATE;

D O I：

10.1002/anie.201107025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Detective work: Three highly sensitive and selective fluorescent probes for the detection of H 2S have been developed. Two of the probes detect H 2S by the reduction of an azide moiety to an amine group, which changes the probes into their fluorescent forms and generates a fluorescent signal. In the third method, the fluorescent signal is created by using H 2S as a nucleophile in a reaction that unmasks fluorescein. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2282 / 2284

页数：3

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