Anti-hepatocarcinoma effects of Aconitum coreanum polysaccharides

被引：46

作者：

Liang, Ming ^{[1
]}

Li, Shuchen ^{[1
]}

Shen, Bin ^{[2
]}

Cai, Jianping ^{[3
]}

Li, Cong ^{[3
]}

Wang, Zhenyu ^{[4
]}

Li, Xiaoguang ^{[1
]}

Gao, Jie ^{[1
]}

Huang, Haiying ^{[1
]}

Zhang, Xiaoyu ^{[1
]}

Li, Jingyuan ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Infect Dis, Harbin 150086, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin 150000, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 3, Dept Pathol, Harbin 150040, Peoples R China

[4] Shenyang Med Coll, Sch Publ Hlth, Shenyang 110034, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 88卷 / 03期

关键词：

Aconitum coreanum; Polysaccharides; Extraction; Antitumor; ANTITUMOR-ACTIVITY; ENHANCEMENT; COMBINATION; CARCINOMA;

D O I：

10.1016/j.carbpol.2012.01.050

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Crude polysaccharides (CACP) were extracted from the stems of Aconitum coreanum by water extraction and ethanol precipitation. In the present investigation, the chemical properties and antitumor activities of CACP were valuated. The results showed the oral administration of CACP could specifically inhibit the growth of H22 tumor cells by in vitro and in vivo model, and exhibited a significant lower cytotoxicity to nontumorous cell lines. Moreover, CACP treatment greatly prolonged the survival period in H22 ascites tumor-bearing mice. After CACP treated, most of H22 cells were arrested in G0/G1 phage determined by flow cytometry. These results suggested CACP exhibited significant antitumor activity, and it possessed a great potential for developing a novel antitumor drug. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：973 / 976

页数：4

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