Lipoprotein(a): Evidence for Role as a Causal Risk Factor in Cardiovascular Disease and Emerging Therapies

被引：28

作者：

Bhatia, Harpreet S. ^{[1
]}

Wilkinson, Michael J. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Cardiovasc Med, La Jolla, CA 92093 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 20期

基金：

美国国家卫生研究院;

关键词：

lipoprotein(a); cardiovascular disease; risk factors; prevention; LOW-DENSITY-LIPOPROTEIN; AORTIC-VALVE STENOSIS; CORONARY-ARTERY-DISEASE; OXIDIZED PHOSPHOLIPIDS; ELEVATED LIPOPROTEIN(A); SERIES-LIPOPROTEIN; TARGETING APOLIPOPROTEIN(A); ANTISENSE OLIGONUCLEOTIDE; REDUCES LIPOPROTEIN(A); MYOCARDIAL-INFARCTION;

D O I：

10.3390/jcm11206040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipoprotein(a) (Lp(a)) is an established risk factor for multiple cardiovascular diseases. Several lines of evidence including mechanistic, epidemiologic, and genetic studies support the role of Lp(a) as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis/calcific aortic valve disease (AS/CAVD). Limited therapies currently exist for the management of risk associated with elevated Lp(a), but several targeted therapies are currently in various stages of clinical development. In this review, we detail evidence supporting Lp(a) as a causal risk factor for ASCVD and AS/CAVD, and discuss approaches to managing Lp(a)-associated risk.

引用

页数：19

共 107 条

[1] Relationship of Apolipoproteins A-1 and B, and Lipoprotein(a) to Cardiovascular Outcomes The AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglyceride and Impact on Global Health Outcomes) [J].

Albers, John J. ;

Slee, April ;

O'Brien, Kevin D. ;

Robinson, Jennifer G. ;

Kashyap, Moti L. ;

Kwiterovich, Peter O., Jr. ;

Xu, Ping ;

Marcovina, Santica M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (17) :1575-1579

[2]

[Anonymous], 2022, AM COLL CARDIOLOGY A

[3]

Arnett DK, 2019, CIRCULATION, V140, pE596, DOI [10.1161/CIR.0000000000000677, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1016/j.jacc.2019.03.009]

[4] Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis A Prospective Mendelian Randomization Study and Replication in a Case-Control Cohort [J].

Arsenault, Benoit J. ;

Boekholdt, S. Matthijs ;

Dube, Marie-Pierre ;

Rheaume, Eric ;

Wareham, Nicholas J. ;

Khaw, Kay-Tee ;

Sandhu, Manjinder S. ;

Tardif, Jean-Claude .

CIRCULATION-CARDIOVASCULAR GENETICS, 2014, 7 (03) :304-310

[5] Lipoprotein(a) levels and risk of future coronary heart disease [J].

Bennet, Anna ;

Di Angelantonio, Ernanuele ;

Erqou, Sebhat ;

Eiriksdottir, Gudny ;

Sigurdsson, Gunnar ;

Woodward, Mark ;

Rumley, Ann ;

Lowe, Gordon D. O. ;

Danesh, John ;

Gudnason, Vilmundur .

ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (06) :598-608

[6]

Berglund L, 2007, AM J CLIN NUTR, V86, P1611

[7] PCSK9 Inhibition and Oxidized Phospholipids [J].

Bhatia, Harpreet S. ;

Yeang, Calvin ;

Baruch, Amos ;

Yang, Xiaohong ;

Stroes, Erik S. G. ;

Tsimikas, Sotirios .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (12) :1288-1289

[8] Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome [J].

Bittner, Vera A. ;

Szarek, Michael ;

Aylward, Philip E. ;

Bhatt, Deepak L. ;

Diaz, Rafael ;

Edelberg, Jay M. ;

Fras, Zlatko ;

Goodman, Shaun G. ;

Halvorsen, Sigrun ;

Hanotin, Corinne ;

Harrington, Robert A. ;

Jukema, J. Wouter ;

Loizeau, Virginie ;

Moriarty, Patrick M. ;

Moryusef, Angele ;

Pordy, Robert ;

Roe, Matthew T. ;

Sinnaeve, Peter ;

Tsimikas, Sotirios ;

Vogel, Robert ;

White, Harvey D. ;

Zahger, Doron ;

Zeiher, Andreas M. ;

Steg, Gabriel ;

Schwartz, Gregory G. ;

Aylward, Philip E. ;

Drexel, Heinz ;

Sinnaeve, Peter ;

Dilic, Mirza ;

Lopes, Renato D. ;

Gotcheva, Nina N. ;

Prieto, Juan-Carlos ;

Yong, Huo ;

Lopez-Jaramillo, Patricio ;

Pecin, Ivan ;

Reiner, Zeljko ;

Ostadal, Petr ;

Poulsen, Steen Hvitfeldt ;

Viigimaa, Margus ;

Nieminen, Markku S. ;

Danchin, Nicolas ;

Chumburidze, Vakhtang ;

Marx, Nikolaus ;

Liberopoulos, Evangelos ;

Montenegro Valdovinos, Pablo Carlos ;

Tse, Hung-Fat ;

Kiss, Robert Gabor ;

Xavier, Denis ;

Zahger, Doron ;

Valgimigli, Marco .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (02) :133-144

[9] Therapeutic Lowering of Lipoprotein(a) A Role for Pharmacogenetics? [J].

Boffa, Michael B. ;

Koschinsky, Marlys L. .

CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2018, 11 (02)

[10] Thematic Review Series: Lipoprotein (a): Coming of Age at Last Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease? [J].

Boffa, Michael B. ;

Koschinsky, Marlys L. .

JOURNAL OF LIPID RESEARCH, 2016, 57 (05) :745-757

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