Long-Term Preclinical Magnetic Resonance Imaging Alterations in Sporadic Creutzfeldt-Jakob Disease

被引：19

作者：

Zanusso, Gianluigi ^{[1
]}

Camporese, Giulia ^{[2
,3
]}

Ferrari, Sergio ^{[1
]}

Santelli, Luca ^{[3
]}

Bongianni, Matilde ^{[1
]}

Fiorini, Michele ^{[1
]}

Monaco, Salvatore ^{[1
]}

Manara, Renzo ^{[4
]}

Cagnin, Annachiara ^{[2
,5
,6
]}

机构：

[1] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[2] Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35128 Padua, Italy

[3] St Antonio Hosp, Neurol Unit, Padua, Italy

[4] Univ Salerno, Dept Med & Surg, Div Neuroradiol, Salerno, Italy

[5] Inst Res, Venice, Italy

[6] Sci Care San Camillo Hosp Fdn, Venice, Italy

来源：

ANNALS OF NEUROLOGY | 2016年 / 80卷 / 04期

关键词：

DIFFUSION-WEIGHTED MRI; DIAGNOSTIC-CRITERIA; SYMPTOM ONSET; ABNORMALITIES; DEMENTIA;

D O I：

10.1002/ana.24757

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1.

引用

页码：629 / 632

页数：4

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