Long-Term Preclinical Magnetic Resonance Imaging Alterations in Sporadic Creutzfeldt-Jakob Disease

被引：19
作者：
Zanusso, Gianluigi [1 ]
Camporese, Giulia [2 ,3 ]
Ferrari, Sergio [1 ]
Santelli, Luca [3 ]
Bongianni, Matilde [1 ]
Fiorini, Michele [1 ]
Monaco, Salvatore [1 ]
Manara, Renzo [4 ]
Cagnin, Annachiara [2 ,5 ,6 ]
机构：
[1] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy
[2] Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35128 Padua, Italy
[3] St Antonio Hosp, Neurol Unit, Padua, Italy
[4] Univ Salerno, Dept Med & Surg, Div Neuroradiol, Salerno, Italy
[5] Inst Res, Venice, Italy
[6] Sci Care San Camillo Hosp Fdn, Venice, Italy
来源：
ANNALS OF NEUROLOGY | 2016年 / 80卷 / 04期
关键词：
DIFFUSION-WEIGHTED MRI; DIAGNOSTIC-CRITERIA; SYMPTOM ONSET; ABNORMALITIES; DEMENTIA;
D O I：
10.1002/ana.24757
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1.
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收藏
页码：629 / 632
页数：4
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