Crosslinking of cellulose derivatives and hyaluronic acid with water-soluble carbodiimide

被引：104

作者：

Sannino, A

Pappadà, S

Madaghiele, M

Maffezzoli, A

Ambrosio, L

Nicolais, L

机构：

[1] Univ Lecce, Dept Innovat Engn, I-73100 Lecce, Italy

[2] CNR, Inst Composite & Biomed Mat, I-80125 Naples, Italy

[3] Univ Naples Federico II, Dept Mat & Prod Engn, I-80125 Naples, Italy

来源：

POLYMER | 2005年 / 46卷 / 25期

关键词：

hydrogel; crosslinking; carbodiimmide;

D O I：

10.1016/j.polymer.2005.10.048

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hydrogels with good mechanical stability are generally obtained by chemical crosslinking. However, the compounds used as crosslinking agents are often highly toxic, and thus they are not recommended as starting materials in view of an environmentally safe production process and a biocompatible product. In this work chemically crosslinked superabsorbent hydrogels have been synthesized from water solutions of hydroxyethylcellulose (HEC), carboxymethylcellulose sodium Salt (CMCNa) and hyaluronic acid (HA), using a non-toxic water-soluble carbodiimide (WSC) as crosslinking agent. Sorption capacity both in water and in water solutions at different ionic strength has been investigated, taking into account the effect of different chemical compositions. Moreover, unaxial compression tests and dynamic-mechanical measurements on water swollen samples have been performed to probe the elastically effective degree of crosslinking of the polymeric network. In vivo tests on humans for the application of this material as a bulking agent in dietary regimes are in process and preliminary results are encouraging. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：11206 / 11212

页数：7

共 27 条

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