Gut microbiome signatures and host colorization with multidrug-resistant bacteria

被引：26

作者：

Isles, Nicole S. ^{[1
,2
]}

Mu, Andre ^{[2
,3
,4
,5
,6
]}

Kwong, Jason C. ^{[2
,7
,8
]}

Howden, Benjamin P. ^{[1
,2
,3
,7
]}

Stinear, Timothy P. ^{[2
,3
]}

机构：

[1] Univ Melbourne, Microbiol Diagnost Unit, Publ Hlth Lab, Peter Doherty Inst Infect & Immun, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic 3000, Australia

[3] Univ Melbourne, Peter Doherty Inst Infect & Immun, Doherty Appl Microbial Genom, Melbourne, Vic 3000, Australia

[4] Salk Inst Biol Studies, Mol & Syst Physiol Lab, La Jolla, CA 92037 USA

[5] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

[6] Salk Inst Biol Studies, NOMIS Ctr Immunobiol & Microbial Pathogenesis, La Jolla, CA 92037 USA

[7] Austin Hlth, Dept Infect Dis, Melbourne, Vic, Australia

[8] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

来源：

TRENDS IN MICROBIOLOGY | 2022年 / 30卷 / 09期

关键词：

COLONIZATION RESISTANCE; PROBIOTICS; DIVERSITY;

D O I：

10.1016/j.tim.2022.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human gut is host to a diverse range of microorganisms that offer protection against colonization by multidrug-resistant bacteria. Antibiotic use, medications, health conditions, and lifestyle factors can alter the composition of the gut micro biota in such a way that results in loss of colonization resistance and increased susceptibility to invading pathogenic antibiotic-resistant bacteria. Therapeutics aiming to restore a diverse and protective microbiome are fast advancing. In this review, we focus on the compositional changes within the gut microbiome that are associated with colonization resistance and discuss their use as potential targets for therapeutics or diagnostics.

引用

页码：853 / 865

页数：13

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