The berkeleyamides, amides from the acid lake fungus Penicillum rubrum

被引：86

作者：

Stierle, Andrea A. ^{[1
]}

Stierle, Donald B. ^{[1
]}

Patacini, Brianna ^{[1
]}

机构：

[1] Montana Tech Univ Montana, Dept Chem & Geochem, Butte, MT 59701 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 05期

关键词：

D O I：

10.1021/np0705054

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A-D (1, 4, 5, 7), isolated from extracts of this fungus. The structures of these compounds were deduced by analysis of NMR data, chemical derivatization, and comparison of their spectroscopic data to those of known compounds.

引用

页码：856 / 860

页数：5

共 29 条

[1] Azaspirene:: A novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartotya sp. [J].

Asami, Y ;

Kakeya, H ;

Onose, R ;

Yoshida, A ;

Matsuzaki, H ;

Osada, H .

ORGANIC LETTERS, 2002, 4 (17) :2845-2848

[2] MATRIX METALLOPROTEINASE INHIBITORS - A NOVEL CLASS OF ANTICANCER AGENTS [J].

BROWN, PD .

ADVANCES IN ENZYME REGULATION, VOL 35, 1995, 35 :293-301

[3] EFFECT OF INTERLEUKIN-1-BETA CONVERTING-ENZYME-INHIBITOR ON ACUTE MYELOGENOUS LEUKEMIA PROGENITOR PROLIFERATION [J].

ESTROV, Z ;

BLACK, RA ;

SLEATH, PR ;

HARRIS, D ;

VAN, Q ;

LAPUSHIN, R ;

ESTEY, EH ;

TALPAZ, M .

BLOOD, 1995, 86 (12) :4594-4602

[4]

Furlan R, 1999, J IMMUNOL, V163, P2403

[5] Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production [J].

Ghayur, T ;

Banerjee, S ;

Hugunin, M ;

Butler, D ;

Herzog, L ;

Carter, A ;

Quintal, L ;

Sekut, L ;

Talanian, R ;

Paskind, M ;

Wong, W ;

Kamen, R ;

Tracey, D ;

Allen, H .

NATURE, 1997, 386 (6625) :619-623

[6] Novel neuritogenic activities of pseurotin A and penicillic acid [J].

Komagata, D ;

Fujita, S ;

Yamashita, N ;

Saito, S ;

Morino, T .

JOURNAL OF ANTIBIOTICS, 1996, 49 (09) :958-959

[7] DIARYL TELLUROXIDES AS NEW MILD OXIDIZING REAGENTS [J].

LEY, SV ;

MEERHOLZ, CA ;

BARTON, DHR .

TETRAHEDRON, 1981, 37 :213-223

[8] Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model [J].

Li, MW ;

Ona, VO ;

Guégan, C ;

Chen, MH ;

Jackson-Lewis, V ;

Andrews, LJ ;

Olszewski, AJ ;

Stieg, PE ;

Lee, JP ;

Przedborski, S ;

Friedlander, RM .

SCIENCE, 2000, 288 (5464) :335-339

[9] Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors [J].

Liedtke, W ;

Cannella, B ;

Mazzaccaro, RJ ;

Clements, JM ;

Miller, KM ;

Wucherpfennig, KW ;

Gearing, AJH ;

Raine, CS .

ANNALS OF NEUROLOGY, 1998, 44 (01) :35-46

[10] Caspase-1 expression in multiple sclerosis plaques and cultured glial cells [J].

Ming, X ;

Li, W ;

Maeda, Y ;

Blumberg, B ;

Raval, S ;

Cook, SD ;

Dowling, PC .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2002, 197 (1-2) :9-18

← 1 2 3 →