Inhibition of class D β-lactamases by acyl phosphates and phosphonates

被引：21
作者：
Adediran, SA
Nukaga, M
Baurin, S
Frère, JM
Pratt, RF [1 ]
机构：
[1] Wesleyan Univ, Dept Chem, Middletown, CT 06459 USA
[2] Jyosai Int Univ, Fac Pharmaceut Sci, Togane, Chiba 2838555, Japan
[3] Univ Liege, Ctr Ingn Prot, B-4000 Sart Tilman Par Liege, Belgium
[4] Univ Liege, Lab Enzymol, B-4000 Sart Tilman Par Liege, Belgium
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 10期
关键词：
D O I：
10.1128/AAC.49.10.4410-4412.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The susceptibility of typical class D beta-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM beta-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.
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收藏
页码：4410 / 4412
页数：3
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