Recovery of state-specific potential of molecular motor from single-molecule trajectory

被引：26
作者：
Toyabe, Shoichi [1 ,2 ]
Ueno, Hiroshi [1 ]
Muneyuki, Eiro [1 ]
机构：
[1] Chuo Univ, Fac Sci & Engn, Tokyo 1128551, Japan
[2] Univ Munich, Fac Phys, D-80339 Munich, Germany
来源：
EPL | 2012年 / 97卷 / 04期
基金：
日本科学技术振兴机构;
关键词：
F-1-ATPASE; ATP; RESOLUTION; ROTATION; HYDROLYSIS; CATALYSIS; ENERGY;
D O I：
10.1209/0295-5075/97/40004
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
We have developed a novel method to evaluate the potential profile of a molecular motor at each chemical state from only the probe's trajectory and applied it to a rotary molecular motor F1-ATPase. By using this method, we could also obtain the information regarding the mechanochemical coupling and energetics. We demonstrate that the position-dependent transition of the chemical states is the key feature for the highly efficient free-energy transduction by F1-ATPase. Copyright (C) EPLA, 2012
引用
收藏
页数：6
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