Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

被引：129
作者：
Souto, Augusto Lopes [1 ]
Tavares, Josean Fechine [1 ]
da Silva, Marcelo Sobral [1 ]
Formiga Melo Diniz, Margareth de Fatima [1 ]
de Athayde-Filho, Petronio Filgueiras [2 ]
Barbosa Filho, Jose Maria [1 ]
机构：
[1] Univ Fed Paraiba, Pharmaceut Technol Lab, BR-58051900 Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Paraiba, Dept Chem, BR-58059900 Joao Pessoa, Paraiba, Brazil
来源：
MOLECULES | 2011年 / 16卷 / 10期
关键词：
alkaloids; anti-inflammatory activity; inflammation; experimental models; review; NATURAL-PRODUCTS; MEDICINAL-PLANTS; TNF-ALPHA; RIPARIN I; ANTIOXIDANT; BERBERINE; TYRAMINE; EXTRACT; MARINE; FANGCHINOLINE;
D O I：
10.3390/molecules16108515
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.
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页码：8515 / 8534
页数：20
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