Advances in tenascin-C biology

被引：262

作者：

Midwood, Kim S. ^{[1
]}

Hussenet, Thomas ^{[2
]}

Langlois, Benoit ^{[2
]}

Orend, Gertraud ^{[2
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol Div, Fac Med, NDORMS, London W6 8LH, England

[2] Univ Strasbourg, Inst Natl Sante & Rech Med, U682, Serv Biol Mol,CHRU Strasbourg,Fac Med,UMR S682, F-67200 Strasbourg, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 19期

关键词：

Tenascin-C; Cardiac injury; Vascular imaging; Stem cells; Tumor metastasis; MATRIX-METALLOPROTEINASE ACTIVITY; MUSCLE-CELL-PROLIFERATION; HUMAN BRAIN-TUMORS; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; MESSENGER-RNA; NEOINTIMAL HYPERPLASIA; MYOCARDIAL-INFARCTION; QUANTITATIVE-ANALYSIS; DYNAMIC EXPRESSION;

D O I：

10.1007/s00018-011-0783-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

引用

页码：3175 / 3199

页数：25

共 199 条

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