High-dose treatment with autologous stem cell transplantation versus sequential chemotherapy: the GELA experience

被引：0

作者：

Bosly, A ^{[1
]}

Haioun, C

Gisselbrecht, C

Reyes, F

Coiffier, B

机构：

[1] Mt Godinne Univ Hosp, Dept Hematol, B-5530 Yvoir, Belgium

[2] Hop St Louis, Paris, France

[3] Hop Henri Mondor, F-94010 Creteil, France

[4] Ctr Hosp Lyon Sud, Lyon, France

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2001年 / 66卷

关键词：

non-Hodgkin's lymphoma; sequential chemotherapy; intensive treatment; autologous stem cell transplantation; relapsing/refractory; stem cell factor;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autologous stem-cell transplantation (ASCT) has permitted to deliver high-dose therapy (HDT). In aggressive lymphomas, the GELA group conducted prospective and retrospective studies comparing HDT + ASCT to conventional sequential chemotherapy. In relapsing patients and in partial remission, retrospective studies showed a survival advantage for HDT + ASCT over sequential chemotherapy. In complete response, advantage for HDT + ASCT was demonstrated in a prospective trial only for patients with high intermediate or high risk in the IPI score. The attainment of a maximal reduction of the tumoral mass before going HDT is very important either in first line or in relapsing patients.

引用

页码：3 / 7

页数：5

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