Organ Preservation in Rectal Cancer

被引：17

作者：

Yuval, Jonathan B. ^{[1
]}

Thompson, Hannah M. ^{[1
]}

Garcia-Aguilar, Julio ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA

来源：

JOURNAL OF GASTROINTESTINAL SURGERY | 2020年 / 24卷 / 08期

关键词：

Nonoperative management; Watch-and-wait; Rectal cancer; Organ preservation; SHORT-COURSE RADIOTHERAPY; CLINICAL COMPLETE RESPONDERS; TOTAL MESORECTAL EXCISION; COURSE RADIATION-THERAPY; PREOPERATIVE CHEMORADIATION; NEOADJUVANT CHEMORADIATION; NONOPERATIVE MANAGEMENT; RANDOMIZED-TRIAL; TUMOR RESPONSE; STOCKHOLM III;

D O I：

10.1007/s11605-020-04583-w

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A proportion of patients with rectal cancer who undergo neoadjuvant treatment end up with a complete pathological response. Because these patients have excellent oncological outcomes, many have questioned if surgical treatment in this population constitutes overtreatment. There is growing interest in watch and wait with selective organ preservation for rectal cancer patients. We review the fundamentals and key considerations of this approach including patient selection, available treatment regimens, assessment of response, long-term monitoring of response, and long-term oncological and functional outcomes.

引用

页码：1880 / 1888

页数：9

共 57 条

[11] Bowel Function 14 Years After Preoperative Short-Course Radiotherapy and Total Mesorectal Excision for Rectal Cancer: Report of a Multicenter Randomized Trial [J].

Chen, Tina Yen-Ting ;

Wiltink, Lisette M. ;

Nout, Remi A. ;

Kranenbarg, Elma Meershoek-Klein ;

Laurberg, Soren ;

Marijnen, Corrie A. M. ;

van de Velde, Cornelis J. H. .

CLINICAL COLORECTAL CANCER, 2015, 14 (02) :106-114

[12] KRAS and Combined KRAS/TP53 Mutations in Locally Advanced Rectal Cancer are Independently Associated with Decreased Response to Neoadjuvant Therapy [J].

Chow, Oliver S. ;

Kuk, Deborah ;

Keskin, Metin ;

Smith, J. Joshua ;

Camacho, Niedzica ;

Pelossof, Raphael ;

Chen, Chin-Tung ;

Chen, Zhenbin ;

Avila, Karin ;

Weiser, Martin R. ;

Berger, Michael F. ;

Patil, Sujata ;

Bergsland, Emily ;

Garcia-Aguilar, Julio .

ANNALS OF SURGICAL ONCOLOGY, 2016, 23 (08) :2548-2555

[13] Short course radiation therapy for rectal cancer in the elderly: can radical surgery be avoided? [J].

Cummings, Michael A. ;

Usuki, Kenneth Y. ;

Fleming, Fergal J. ;

Tejani, Mohainedtaki A. ;

Katz, Alan W. .

JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2019, 10 (02) :357-361

[14] Colorectal cancer [J].

Cunningham, David ;

Atkin, Wendy ;

Lenz, Heinz-Josef ;

Lynch, Henry T. ;

Minsky, Bruce ;

Nordlinger, Bernard ;

Starling, Naureen .

LANCET, 2010, 375 (9719) :1030-1047

[15] Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer [J].

Das, Prajnan ;

Skibber, John M. ;

Rodriguez-Bigas, Miguel A. ;

Feig, Barry W. ;

Chang, George J. ;

Wolff, Robert A. ;

Eng, Cathy ;

Krishnan, Sunil ;

Jarl, Nora A. ;

Crane, Christopher H. .

CANCER, 2007, 109 (09) :1750-1755

[16] DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics [J].

de Rosa, Nicole ;

Rodriguez-Bigas, Miguel A. ;

Chang, George J. ;

Veerapong, Jula ;

Borras, Ester ;

Krishnan, Sunil ;

Bednarski, Brian ;

Messick, Craig A. ;

Skibber, John M. ;

Feig, Barry W. ;

Lynch, Patrick M. ;

Vilar, Eduardo ;

You, Y. Nancy .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (25) :3039-+

[17] A watch-and-wait approach for locally advanced rectal cancer after a clinical complete response following neoadjuvant chemoradiation: a systematic review and meta-analysis [J].

Dossa, Fahima ;

Chesney, Tyler R. ;

Acuna, Sergio A. ;

Baxter, Nancy N. .

LANCET GASTROENTEROLOGY & HEPATOLOGY, 2017, 2 (07) :501-513

[18] Optimal Interval to Surgery After Neoadjuvant Chemoradiotherapy in Rectal Cancer: A Systematic Review and Meta-analysis [J].

Du, Donglin ;

Su, Zhourong ;

Wang, Dan ;

Liu, Wenwen ;

Wei, Zhengqiang .

CLINICAL COLORECTAL CANCER, 2018, 17 (01) :13-24

[19] Local excision of T1 and T2 rectal cancer: proceed with caution [J].

Elmessiry, M. M. ;

Van Koughnett, J. A. M. ;

Maya, A. ;

DaSilva, G. ;

Wexner, S. D. ;

Bejarano, P. ;

Berho, M. .

COLORECTAL DISEASE, 2014, 16 (09) :703-709

[20] Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial [J].

Erlandsson, Johan ;

Holm, Torbjorn ;

Pettersson, David ;

Berglund, Ake ;

Cedermark, Bjorn ;

Radu, Calin ;

Johansson, Hemming ;

Machado, Mikael ;

Hjern, Fredrik ;

Hallbook, Olof ;

Syk, Ingvar ;

Glimelius, Bengt ;

Martling, Anna .

LANCET ONCOLOGY, 2017, 18 (03) :336-346

← 1 2 3 4 5 6 →