A Compound Isolated from Rumex japonicus Induces Early Growth Response Gene-I Expression

被引：10

作者：

Jo, Geunhyeong ^{[1
]}

Shin, Soon Young ^{[2
]}

Lee, Younggiu ^{[1
]}

Hyun, Jiye ^{[1
]}

Dong, Kwang Sik ^{[1
]}

Park, Jun Cheol ^{[3
]}

Kim, Hyun Su ^{[4
]}

Lee, Young Han ^{[2
]}

Lim, Yoongho ^{[1
]}

机构：

[1] Konkuk Univ, BMIC, Div Biosci & Biotechnol, Seoul 143701, South Korea

[2] Konkuk Univ, Dept Biomed Sci & Technol, RCTC, SMART Inst Adv Biomed Sci, Seoul 143701, South Korea

[3] Rural Dev Adm, Natl Inst Anim Sci, Suwon 441706, South Korea

[4] Int Univ Korea, Dept Pharmaceut Engn, Gyungnam 660759, South Korea

来源：

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2011年 / 54卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

clonogenic assay; early growth response-1 gene; flavonoid; parietin; Rumex japonicus; TRANSCRIPTION FACTOR EGR-1; GLIOMA-CELLS; INDUCED APOPTOSIS; PROTEIN; ACTIVATION; SEQUENCES; CANCER; MOUSE; TRIFLUOPERAZINE; INDUCTION;

D O I：

10.3839/jksabc.2011.097

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.

引用

页码：637 / 643

页数：7

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