Apolipoprotein E polymorphism as a predictor for cognitive decline and dementia in the Saudi general population over 65 years

被引：3

作者：

Al-Khedhairy, AAA ^{[1
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia

来源：

GENETICS AND MOLECULAR BIOLOGY | 2004年 / 27卷 / 03期

关键词：

ApoE; Alzheimer's disease; dementia; Saudi population;

D O I：

10.1590/S1415-47572004000300004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Specific Apolipoprotein E (ApoE) genotypes are thought to be associated with risk for Alzheimer's disease (AD). It is essential to understand how this genetic factor affects cognitive decline and dementia in the general population. One hundred and fifty elderly persons residing at social nursing centers in different provinces of Saudi Arabia were tested for ApoE genotypes, using PCR amplification of genomic DNA followed by DNA digestion with Cfo 1. All subjects were diagnosed with regard to cognitive decline and dementia. In the general Saudi population, the ApoE4 allele was found to be a weaker predictor for dementia than for AD. This may be a result of non-AD pathological processes and/or of most prevalent dementia at an age when the ApoE4 effect on the AD/dementia risk has decreased.

引用

页码：331 / 334

页数：4

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