Glutamatergic receptor and neuroplasticity in depression: Implications for ketamine and rapastinel as the rapid-acting antidepressants

被引：33

作者：

Wang, Ya-Ting ^{[1
]}

Zhang, Ning-Ning ^{[2
,3
]}

Liu, Ling-Jie ^{[1
]}

Jiang, Hong ^{[2
,3
]}

Hu, Die ^{[1
]}

Wang, Zhen-Zhen ^{[2
,3
]}

Chen, Nai-Hong ^{[2
,3
]}

Zhang, Yi ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Med, Dept Anat, Sunshine Southern Ave, Beijing 102488, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, 1 Xian Nong Tan St, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, 1 Xian Nong Tan St, Beijing 100050, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 594卷

基金：

中国国家自然科学基金;

关键词：

Depression; Ketamine; Rapastinel; N-methyl-D-aspartate receptor; Review; FUNCTIONAL PARTIAL AGONIST; MEDIAL PREFRONTAL CORTEX; NMDA RECEPTORS; SYNAPTIC PLASTICITY; LATERAL HABENULA; AMPA RECEPTORS; NEUROTROPHIN RECEPTOR; MONOCLONAL-ANTIBODY; MAJOR DEPRESSION; MAMMALIAN TARGET;

D O I：

10.1016/j.bbrc.2022.01.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose of review: To explore the convergent downstream pathways of ketamine and rapastinel and drive further development of identification for following generational rapid-acting antidepressants in the synaptic process. Recent findings: Ketamine is an NMDAR antagonist and is proven effective in depression for the rapid and sustained antidepressant response, while rapastinel is an NMDAR positive allosteric modulator, producing antidepressant effects like ketamine with no severe side effects. The common antidepressant effects of ketamine and rapastinel are BDNF and mTORC1 pathway in synaptic plasticity. (C) 2022 Elsevier Inc. All rights reserved.

引用

页码：46 / 56

页数：11

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