CT Nonuniform Attenuation and TEW Scatter Corrections in Brain Tc-99m ECD SPECT

被引：9

作者：

Farid, Karim ^{[1
]}

Habert, Marie-Odile ^{[2
,3
]}

Martineau, Antoine ^{[4
]}

Caillat-Vigneron, Nadine ^{[1
,5
]}

Sibon, Igor ^{[6
,7
,8
]}

机构：

[1] Hop Hotel Dieu, AP HP, Nucl Med Serv, F-75181 Paris, France

[2] Grp Hosp Pitie Salpetriere, AP HP, Nucl Med Serv, F-75634 Paris, France

[3] Univ Paris 06, INSERM, UMR S 678, Paris, France

[4] St Louis Hosp, Dept Nucl Med, Paris, France

[5] Univ Paris 05, Paris, France

[6] Univ Bordeaux 2, F-33076 Bordeaux, France

[7] Univ Hosp Bordeaux, Bordeaux, France

[8] CNRS, UMR 5231, Bordeaux, France

来源：

CLINICAL NUCLEAR MEDICINE | 2011年 / 36卷 / 08期

关键词：

Tc-99m ECD SPECT/CT; attenuation correction; Alzheimer disease; cerebral blood flow; CEREBRAL-BLOOD-FLOW; COMPUTED-TOMOGRAPHY; DISTRIBUTIONS; QUANTIFICATION; COMPENSATION; TRANSMISSION; VOLUNTEERS;

D O I：

10.1097/RLU.0b013e318217544c

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Perfusion brain single photon emission computed tomography (SPECT) is currently used to evaluate patients with cognitive impairments. Although widely available, it has been reported to be significantly less sensitive than F-18 FDG positron emission tomography. Optimization of SPECT parameters using nonuniform attenuation correction (NUAC) and scatter correction (SC) might improve the accuracy of the method. This study assessed the effect of x-ray CT-based NUAC and triple-energy window (TEW-SC) on brain SPECT compared with Chang-uniform (UAC). A total of 31 patients with memory complaints underwent Tc-99m ECD SPECT/CT. CT-NUAC + TEW-SC and Chang-UAC were applied and compared. The images were spatially normalized to a default SPECT template supplied with Statistical Parametric Mapping software (SPM2). A paired t test image was then reconstructed. Regional cerebral blood flow measurements were apparently reduced in the frontal white-matter and in the frontotemporal cortex when CT-NUAC + TEW-SC were used. These findings need to be considered when interpreting Tc-99m ECD SPECT after applying CT-AC + TEW-SC. Further prospective studies with clinical correlations are needed.

引用

页码：665 / 668

页数：4

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