HIV type 2 intergroup recombinant identified in Cameroon

被引：17

作者：

Yamaguchi, Julie ^{[1
]}

Vallari, Ana ^{[1
]}

Ndembi, Nicaise ^{[2
]}

Coffey, Ruthie ^{[1
]}

Ngansop, Charlotte ^{[2
]}

Mbanya, Dora ^{[2
]}

Kaptue, Lazare ^{[2
,3
]}

Guertler, Lutz G. ^{[4
]}

Devare, Sushil G. ^{[1
]}

Brennan, Catherine A. ^{[1
]}

机构：

[1] Abbott Diagnost, Dept 09NG, Abbott Pk, IL 60064 USA

[2] Univ Yaounde, Yaounde, Cameroon

[3] Univ Montagnes, Bangangte, Cameroon

[4] Ernst Moritz Arndt Univ Greifswald, Loeffler Inst, D-17498 Greifswald, Germany

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2008年 / 24卷 / 01期

关键词：

D O I：

10.1089/aid.2007.0190

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A unique HIV-2 intergroup recombinant strain was identified in Cameroon. The virus, CM-03-510-03, was amplified from blood collected from a 47-year-old female patient in Douala, Cameroon in 2003 who was seroreactive for HIV-2. A near full-length genome 9089 nucleotides in length was amplified from proviral DNA. The genome for CM-03-510-03 is composed of segments of HIV-2 groups A and B with four recombination breakpoints and has open reading frames for all the structural and regulatory genes. A comparison of CM-03-51003 to the only previously reported HIV-2 intergroup recombinant shows that the two strains share one recombination breakpoint but are otherwise distinct from each other. Similar to HIV-1, HIV-2 intergroup recombination is an indication that coinfection with more than one strain has occurred in individuals and is a mechanism that increases strain genetic diversity.

引用

页码：86 / 91

页数：6

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