Examining the interseasonal resurgence of respiratory syncytial virus in Western Australia

被引:119
作者
Foley, David Anthony [1 ,2 ]
Phuong, Linny Kimly [3 ]
Peplinski, Joseph [4 ]
Lim, Selina Mei [5 ]
Lee, Wei Hao [4 ]
Farhat, Asifa [4 ]
Minney-Smith, Cara A. [1 ]
Martin, Andrew C. [4 ]
Mace, Ariel O. [4 ]
Sikazwe, Chisha T. [1 ,6 ]
Le, Huong [2 ]
Levy, Avram [1 ,6 ]
Hoeppner, Tobias [7 ]
Borland, Meredith L. [7 ,8 ,9 ]
Hazelton, Briony [1 ,5 ]
Moore, Hannah C. [2 ]
Blyth, Christopher [1 ,2 ,10 ]
Yeoh, Daniel K. [5 ]
Bowen, Asha C. [2 ,5 ]
机构
[1] PathWest Lab Med, Microbiol, Perth, WA 6009, Australia
[2] Univ Western Australia, Wesfarmers Ctr Vaccines & Infect Dis, Telethon Kids Inst, Nedlands, WA, Australia
[3] Murdoch Childrens Res Inst, Infect & Immun, Parkville, Vic, Australia
[4] Perth Childrens Hosp, Dept Gen Paediat, Nedlands, WA, Australia
[5] Perth Childrens Hosp, Infect Dis Dept, Perth, WA, Australia
[6] Univ Western Australia, Biomed Sci, Infect & Immun, Perth, WA, Australia
[7] Perth Childrens Hosp, Emergency Med, Nedlands, WA, Australia
[8] Univ Western Australia, Div Paediat, Crawley, WA, Australia
[9] Univ Western Australia, Div Emergency Med, Crawley, WA, Australia
[10] Univ Western Australia, Sch Paediat & Child Hlth, Subiaco, WA, Australia
基金
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
PUBLIC-HEALTH MEASURES; INFECTION; CHILDREN; BURDEN; RISK; SEASONALITY; INFANTS; IMPACT;
D O I
10.1136/archdischild-2021-322507
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background Following a relative absence in winter 2020, a large resurgence of respiratory syncytial virus (RSV) detections occurred during the 2020/2021 summer in Western Australia. This seasonal shift was linked to SARS-CoV-2 public health measures. We examine the epidemiology and RSV testing of respiratory-coded admissions, and compare clinical phenotype of RSV-positive admissions between 2019 and 2020. Method At a single tertiary paediatric centre, International Classification of Diseases, 10th edition Australian Modification-coded respiratory admissions longer than 12 hours were combined with laboratory data from 1 January 2019 to 31 December 2020. Data were grouped into bronchiolitis, other acute lower respiratory infection (OALRI) and wheeze, to assess RSV testing practices. For RSV-positive admissions, demographics and clinical features were compared between 2019 and 2020. Results RSV-positive admissions peaked in early summer 2020, following an absent winter season. Testing was higher in 2020: bronchiolitis, 94.8% vs 89.2% (p=0.01); OALRI, 88.6% vs 82.6% (p=0.02); and wheeze, 62.8% vs 25.5% (p<0.001). The 2020 peak month, December, contributed almost 75% of RSV-positive admissions, 2.5 times the 2019 peak. The median age in 2020 was twice that observed in 2019 (16.4 vs 8.1 months, p<0.001). The proportion of RSV-positive OALRI admissions was greater in 2020 (32.6% vs 24.9%, p=0.01). There were no clinically meaningful differences in length of stay or disease severity. Interpretation The 2020 RSV season was in summer, with a larger than expected peak. There was an increase in RSV-positive non-bronchiolitis admissions, consistent with infection in older RSV-naive children. This resurgence raises concern for regions experiencing longer and more stringent SARS-CoV-2 public health measures.
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页数:7
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