Small RNAs Play Big Roles: MicroRNAs in Diabetic Wound Healing

被引：2
作者：
Fahs, F. [1 ,2 ,3 ]
Bi, X. -L. [1 ,2 ,4 ]
Yu, F. -S. [5 ,6 ]
Zhou, L. [1 ,2 ,7 ]
Mi, Q. -S. [1 ,2 ,7 ]
机构：
[1] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA
[2] Henry Ford Hlth Syst, Henry Ford Immunol Program, Detroit, MI USA
[3] Oakland Univ, William Beaumont Sch Med, Rochester, MI 48063 USA
[4] Changhai Hosp, Dept Dermatol, Shanghai, Peoples R China
[5] Wayne State Univ, Sch Med, Dept Ophthalmol, Detroit, MI USA
[6] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA
[7] Henry Ford Hlth Syst, Dept Internal Med, Detroit, MI USA
来源：
CURRENT MOLECULAR MEDICINE | 2016年 / 16卷 / 06期
关键词：
microRNA; wound healing; skin; cornea; diabetes; pathogenesis; INSULIN-RESISTANCE; DOWN-REGULATION; CELL-FUNCTION; EXPRESSION; TYPE-2; IMPAIRMENT; IDENTIFICATION; PROLIFERATION; PATHOGENESIS; CONTRIBUTES;
D O I：
10.2174/1566524016666160607091156
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Skin and corneal wounds in diabetics are a major healthcare burden. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate the expression of protein-coding genes. Studies have identified microRNAs involved in all phases of wound healing. The dysregulation of microRNAs can contribute to impaired or delayed skin and corneal wound healing in diabetics. Here, we present a comprehensive review of the literature involving microRNAs in diabetic skin and corneal wound healing as well as those serving as potential biomarkers for diabetic wound healing.
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收藏
页码：545 / 552
页数：8
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