Baseline relative eosinophil count as a predictive biomarker for ipilimumab treatment in advanced melanoma

被引：27

作者：

Ferrucci, Pier Francesco ^{[1
]}

Gandini, Sara ^{[2
]}

Cocorocchio, Emilia ^{[1
]}

Pala, Laura ^{[1
]}

Baldini, Federica ^{[3
]}

Mosconi, Massimo ^{[3
]}

Cappellini, Gian Carlo Antonini ^{[4
]}

Albertazzi, Elena ^{[2
]}

Martinoli, Chiara ^{[1
]}

机构：

[1] European Inst Oncol, Div Med Oncol Melanoma & Sarcoma, Med Oncol Melanoma Unit, Milan, Italy

[2] European Inst Oncol, Div Epidemiol & Biostat, Milan, Italy

[3] European Inst Oncol, Div Surg Melanoma & Sarcoma, Milan, Italy

[4] Ist Dermopat Immacolata IRCCS, Oncol Div 4, Rome, Italy

来源：

ONCOTARGET | 2017年 / 8卷 / 45期

关键词：

eosinophil; predictive; biomarker; ipilimumab; melanoma; TO-LYMPHOCYTE RATIO; METASTATIC MELANOMA; PEMBROLIZUMAB; SURVIVAL; TRIAL;

D O I：

10.18632/oncotarget.19748

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As diverse therapeutic options are now available for advanced melanoma patients, predictive markers that may assist treatment decision are needed. A model based on baseline serum lactate dehydrogenase (LDH), peripheral blood relative lymphocyte counts (RLC) and eosinophil counts (REC) and pattern of distant metastasis, has been recently proposed for pembrolizumab-treated patients. Here, we applied this model to advanced melanoma patients receiving chemotherapy (n = 116) or antiCTLA-4 therapy (n = 128). Visceral involvement, LDH and RLC were associated with prognosis regardless of treatment. Instead, when compared to chemotherapy-treated patients with REC < 1.5%, those with REC >= 1.5% had improved overall survival when receiving anti-CTLA-4 [Hazard Ratio (HR) = 0.56 (0.4-0.93)] but not chemotherapy [HR = 1.13, (0.74-1.74)], and the treatment-by-REC interaction was significant for both overall (p = 0.04) and progression free survival (p = 0.009). These results indicate baseline REC >= 1.5% as a candidate predictive biomarker for benefit from anti-CTLA-4. Further studies are needed to confirm these findings in patients receiving immune-modulating agents.

引用

页码：79809 / 79815

页数：7

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