Synthesis of new fused pyrimidines by isocyanate and isothiocyanate

被引：18

作者：

Chowdhury, AZMS ^{[1
]}

Shibata, Y ^{[1
]}

机构：

[1] Natl Inst Environm Studies, Environm Chem Div, Tsukuba, Ibaraki 3050053, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 04期

关键词：

fused pyrimidine; urethane; displacement reaction; isothiocyanate; isocyanate; o-aminonitrile or ester compound;

D O I：

10.1248/cpb.49.391

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

o-Aminonitrile or o-aminoester compounds were cyclized to fused pyrimidines by reacting with ethyl iso(thio)cyanatoacetate in pyridine, and then were methylated, halogenated and subsequently displaced by the amines studied.

引用

页码：391 / 395

页数：5

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