Evaluation of a Transgenic Mouse Model of Multiple Sclerosis with Noninvasive Methods

被引：19

作者：

Enriquez-Algeciras, Mabel

Ding, Di ^{[2
]}

Chou, Tsung-Han

Wang, Jianhua

Padgett, Kyle R. ^{[3
]}

Porciatti, Vittorio

Bhattacharya, Sanjoy K. ^{[1
,2
]}

机构：

[1] Univ Miami, Dept Ophthalmol, Bascom Palmer Eye Inst, Miami, FL 33136 USA

[2] Univ Miami, Dept Biochem & Mol Biol, Miami, FL 33136 USA

[3] Univ Miami, Dept Radiol, Miami, FL 33136 USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2011年 / 52卷 / 05期

基金：

美国国家卫生研究院;

关键词：

OPTICAL COHERENCE TOMOGRAPHY; CENTRAL-NERVOUS-SYSTEM; DEMYELINATION; DISEASE; EXPRESSION; PLUS; MICE; PERG;

D O I：

10.1167/iovs.10-6425

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods. METHODS. Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis. RESULTS. Electrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate with neurologic/behavioral abnormalities. In ND4 mice, the authors found PERG abnormalities preceded neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities. CONCLUSIONS. The ND4 mouse model has been evaluated using well-defined parameters of noninvasive methods (PERG, MRI, and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality. (Invest Ophthalmol Vis Sci. 2011; 52: 2405-2411) DOI: 10.1167/iovs.10-6425

引用

页码：2405 / 2411

页数：7

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