Evidence for GABAergic inhibitory deficits in major depressive disorder

被引：118
作者：
Croarkin, Paul E. [2 ]
Levinson, Andrea J.
Daskalakis, Zafiris J. [1 ]
机构：
[1] Univ Toronto, Fac Med, Ctr Addict & Mental Hlth, Dept Psychiat, Toronto, ON M5T 1R8, Canada
[2] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2011年 / 35卷 / 03期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
Major depressive disorder; Cortical inhibition; GABA; Transcranial magnetic stimulation; Interneuron; GAMMA-AMINOBUTYRIC-ACID; TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX EXCITABILITY; INCREASED CORTICAL INHIBITION; OCCIPITAL CORTEX; GABA CONCENTRATIONS; SILENT PERIOD; SUICIDE BRAIN; RECEPTORS; SEROTONIN;
D O I：
10.1016/j.neubiorev.2010.10.002
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Converging evidence suggests that deficits in gamma-aminobutyric acid (GABA) functioning are implicated in the pathophysiology of major depressive disorder (MDD). This is highlighted by research investigating cortical inhibition (Cl), a process whereby GABAergic interneurons selectively attenuate pyramidal neurons. Transcranial magnetic stimulation (TMS) paradigms evaluate this marker of neuronal inhibitory activity in the cortex. This review will examine the neuroanatomic and neurophysiological evidence from neuroimaging, molecular, treatment, and TMS studies linking dysfunctional GABAergic neurotransmission to MDD. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：818 / 825
页数：8
相关论文
共 80 条
  • [21] A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression
    De La Garza, R
    Mahoney, JJ
    [J]. BRAIN RESEARCH, 2004, 1021 (02) : 209 - 218
  • [22] Fassio A, 1999, J NEUROSCI RES, V57, P324, DOI 10.1002/(SICI)1097-4547(19990801)57:3<324::AID-JNR4>3.3.CO
  • [23] 2-Q
  • [24] Motor cortical excitability and clinical response to rTMS in depression
    Fitzgerald, PB
    Brown, TL
    Marston, NAU
    Daskalakis, ZJ
    de Castella, A
    Bradshaw, JL
    Kulkarni, J
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 2004, 82 (01) : 71 - 76
  • [25] SEROTONERGIC CONTROL OF THE HIPPOCAMPUS VIA LOCAL INHIBITORY INTERNEURONS
    FREUND, TF
    GULYAS, AI
    ACSADY, L
    GORCS, T
    TOTH, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) : 8501 - 8505
  • [26] PYRAMIDAL CELLS IN PIRIFORM CORTEX RECEIVE A CONVERGENCE OF INPUTS FROM MONOAMINE ACTIVATED GABAERGIC INTERNEURONS
    GELLMAN, RL
    AGHAJANIAN, GK
    [J]. BRAIN RESEARCH, 1993, 600 (01) : 63 - 73
  • [27] GERNER RH, 1981, AM J PSYCHIAT, V138, P1098
  • [28] GOLD BI, 1980, AM J PSYCHIAT, V137, P362
  • [29] Reduced prefrontal glutamate/glutamine and γ-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy
    Hasler, Gregor
    van der Veen, Jan Willem
    Tumonis, Toni
    Meyers, Noah
    Shen, Jun
    Drevets, Wayne C.
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (02) : 193 - 200
  • [30] Jakab RL, 2000, J COMP NEUROL, V417, P337, DOI 10.1002/(SICI)1096-9861(20000214)417:3<337::AID-CNE7>3.0.CO
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