Evidence for GABAergic inhibitory deficits in major depressive disorder

被引：118
作者：
Croarkin, Paul E. [2 ]
Levinson, Andrea J.
Daskalakis, Zafiris J. [1 ]
机构：
[1] Univ Toronto, Fac Med, Ctr Addict & Mental Hlth, Dept Psychiat, Toronto, ON M5T 1R8, Canada
[2] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2011年 / 35卷 / 03期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
Major depressive disorder; Cortical inhibition; GABA; Transcranial magnetic stimulation; Interneuron; GAMMA-AMINOBUTYRIC-ACID; TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX EXCITABILITY; INCREASED CORTICAL INHIBITION; OCCIPITAL CORTEX; GABA CONCENTRATIONS; SILENT PERIOD; SUICIDE BRAIN; RECEPTORS; SEROTONIN;
D O I：
10.1016/j.neubiorev.2010.10.002
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Converging evidence suggests that deficits in gamma-aminobutyric acid (GABA) functioning are implicated in the pathophysiology of major depressive disorder (MDD). This is highlighted by research investigating cortical inhibition (Cl), a process whereby GABAergic interneurons selectively attenuate pyramidal neurons. Transcranial magnetic stimulation (TMS) paradigms evaluate this marker of neuronal inhibitory activity in the cortex. This review will examine the neuroanatomic and neurophysiological evidence from neuroimaging, molecular, treatment, and TMS studies linking dysfunctional GABAergic neurotransmission to MDD. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：818 / 825
页数：8
相关论文
共 80 条
  • [1] 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex
    Abi-Saab, WM
    Bubser, M
    Roth, RH
    Deutch, AY
    [J]. NEUROPSYCHOPHARMACOLOGY, 1999, 20 (01) : 92 - 96
  • [2] GABA(A) RECEPTORS MEDIATE THE CHANGES PRODUCED BY STRESS ON GABA FUNCTION AND LOCOMOTOR-ACTIVITY
    ACOSTA, GB
    RUBIO, MC
    [J]. NEUROSCIENCE LETTERS, 1994, 176 (01) : 29 - 31
  • [3] The epidemiology of major depressive episodes:: results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys
    Andrade, L
    Caraveo-Anduaga, JJ
    Berglund, P
    Bijl, RV
    De Graaf, R
    Vollebergh, W
    Dragomirecka, E
    Kohn, R
    Keller, M
    Kessler, RC
    Kawakami, N
    Kiliç, C
    Offord, D
    Ustun, TB
    Wittchen, HU
    [J]. INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, 2003, 12 (01) : 3 - 21
  • [4] Evidence for impaired cortical inhibition in patients with unipolar major depression
    Bajbouj, M
    Lisanby, SH
    Lang, UE
    Danker-Hopfe, H
    Heuser, I
    Neu, P
    [J]. BIOLOGICAL PSYCHIATRY, 2006, 59 (05) : 395 - 400
  • [5] Effects of right unilateral electroconvulsive therapy on motor cortical excitability in depressive patients
    Bajbouj, Malek
    Lang, Undine E.
    Niehaus, Ludwig
    Hellen, Florence E.
    Heuser, Isabella
    Neu, Peter
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 2006, 40 (04) : 322 - 327
  • [6] Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression
    Bewernick, Bettina H.
    Hurlemann, Rene
    Matusch, Andreas
    Kayser, Sarah
    Grubert, Christiane
    Hadrysiewicz, Barbara
    Axmacher, Nikolai
    Lemke, Matthias
    Cooper-Mahkorn, Deirdre
    Cohen, Michael X.
    Brockmann, Holger
    Lenartz, Doris
    Sturm, Volker
    Schlaepfer, Thomas E.
    [J]. BIOLOGICAL PSYCHIATRY, 2010, 67 (02) : 110 - 116
  • [7] Reduction in occipital cortex γ-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects
    Bhagwagar, Zubin
    Wylezinska, Marzena
    Jezzard, Peter
    Evans, John
    Ashworth, Fiona
    Sule, Akeem
    Matthews, Paul M.
    Cowen, Philip J.
    [J]. BIOLOGICAL PSYCHIATRY, 2007, 61 (06) : 806 - 812
  • [8] rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest
    Boshuisen, ML
    Ter Horst, GJ
    Paans, AMJ
    Reinders, AATS
    den Boer, JA
    [J]. BIOLOGICAL PSYCHIATRY, 2002, 52 (02) : 126 - 135
  • [9] GABA-B RECEPTOR PHARMACOLOGY
    BOWERY, NG
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1993, 33 : 109 - 147
  • [10] (-) BACLOFEN DECREASES NEUROTRANSMITTER RELEASE IN THE MAMMALIAN CNS BY AN ACTION AT A NOVEL GABA RECEPTOR
    BOWERY, NG
    HILL, DR
    HUDSON, AL
    DOBLE, A
    MIDDLEMISS, DN
    SHAW, J
    TURNBULL, M
    [J]. NATURE, 1980, 283 (5742) : 92 - 94
12345678