Emergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis

被引：22

作者：

de Dios Caballero, Juan ^{[1
,2
,3
]}

Dolores Pastor, Maria ^{[4
]}

Vindel, Ana ^{[5
]}

Maiz, Luis ^{[6
]}

Yague, Genoveva ^{[7
]}

Salvador, Carme ^{[7
]}

Cobo, Marta ^{[1
,2
]}

Morosini, Maria-Isabel ^{[1
,2
,3
]}

del Campo, Rosa ^{[1
,2
,3
]}

Canton, Rafael ^{[1
,2
,3
]}

机构：

[1] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain

[2] Inst Ramon y Cajal Invest Sanitaria, Madrid, Spain

[3] REIPI, Madrid, Spain

[4] Hosp Univ Virgen Arrixaca, Serv Neumol, Murcia, Spain

[5] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Bacteriol, Staphylococcus Reference Lab, Madrid, Spain

[6] Hosp Univ Ramon y Cajal, Serv Neumol, Madrid, Spain

[7] Hosp Univ Virgen Arrixaca, Microbiol Serv, Murcia, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 03期

关键词：

CLINICAL ISOLATE; GENE; MECHANISMS; INFECTION; STRAIN;

D O I：

10.1128/AAC.02067-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Resistance to linezolid (LZD) in methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with cystic fibrosis (CF) is due mainly to ribosomal mutations. We report on four CF patients with LZD-resistant MRSA bronchopulmonary infections by strains carrying the cfr gene. Strains from one patient also harbored the G2576U mutation (23S rRNA) and the G139R substitution (L3 protein). All strains belonged to the epidemic clone ST125 MRSA IVc. Our results support the monitoring of LZD resistance emergence in CF and non-CF MRSA isolates.

引用

页码：1878 / 1882

页数：5

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