Chemical Composition and Antibacterial Activity of the Lippia origanoides Kunth Essential Oil from the Caraj ′as National Forest, Brazil

被引：12
作者：
Ribeiro, Fabiana Paiva [1 ]
de Oliveira, Mozaniel Santana [2 ]
Feitosa, Andre de Oliveira [3 ]
Barbosa Marinho, Patricia Santana [3 ]
do Rosario Marinho, Andrey Moacir [3 ]
de Aguiar Andrade, Eloisa Helena [2 ,3 ]
Ribeiro, Alcy Favacho [1 ]
机构：
[1] Fed Univ Para, Fac Chem, Ananindeua Campus,Tv We Vinte & Seis 2, BR-67130660 Coqueiro, Ananindeua, Brazil
[2] Adolpho Ducke Lab, Bot Coordinat, Emilio Goeldi Museum, Av Perimetral 1901, BR-66077830 Belem, Para, Brazil
[3] Fed Univ Para, Fac Chem, R Augusto Correa,01 Guama, BR-66075110 Belem, Para, Brazil
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2021年 / 2021卷
关键词：
ALBA ESSENTIAL OIL; ANTIMICROBIAL ACTIVITY; ALPHA-PINENE; 1,8-CINEOLE; VERBENACEAE; CHEMOTYPE; EFFICACY; FOOD;
D O I：
10.1155/2021/9930336
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Species of the genus Lippia are rich in essential oils and have shown antibacterial properties, which may be related to oils' chemical composition. The present work aimed to evaluate the antimicrobial potential of Lippia origanoides Kunth against two bacteria strains: Escherichia coli and Staphylococcus aureus. Leaf essential oils were obtained by hydrodistillation in a modified Clevenger-type apparatus, and their chemical composition was determined by gas chromatography coupled to mass spectrometry (GC/MS) and flame ionization detection (GC/FID). We identified 28 compounds, representing 98.87% of the total concentration of the essential oil. The compounds identified at the highest concentrations were 1,8-cineole (35.04%), carvacrol (11.32%), p-cymene (8.53%), a-pinene (7.17%), and c-terpinene (7.16%). The leaf essential oil of L. origanoides showed antibacterial action on biological isolates of Escherichia coli and Staphylococcus aureus. For Escherichia coli, the oil presented bactericidal action at concentrations of 5-20 mu L/mL. Regarding Staphylococcus aureus, the bactericidal effect was noted at 20 mu L/mL and the bacteriostatic action was noted around 2.5-10 mu L/mL. Given the results obtained, L. origanoides essential oil showed promising biological potential against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, thus encouraging further studies on substances isolated from this species to contribute to the development of new antimicrobial drugs.
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