Synthesis and Biological Activity of 4H-Thieno[3,2-c]Chromene Derivatives

被引：8

作者：

Bogza, Yu. P. ^{[1
]}

Katsiel', A. L. ^{[1
]}

Sharypova, A. N. ^{[1
]}

Tolstikova, T. G. ^{[2
]}

Fisyuk, A. S. ^{[1
,3
]}

机构：

[1] FM Dostoevskii Omsk State Univ, Omsk 644077, Russia

[2] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

[3] Omsk State Tech Univ, Omsk 644050, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 50卷 / 12期

基金：

俄罗斯基础研究基金会;

关键词：

4H-thieno[3,2-c]chromene; antiulcer activity; electrophilic substitution; oxidation; reduction;

D O I：

10.1007/s10593-015-1642-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formyl group of 4H-thieno[3,2-c]chromene-2-carbaldehyde was transformed into the respective nitrile, amide, ester, carboxylic, hydroxamic, or hydroxy group. Electrophilic substitution in 4H-thieno[3,2-c]chromene-2-carbaldehyde was shown to occur at the D-8 atom, while oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in methanol led to 4-methoxy-4H-thieno[3,2-c]chromene-2-carbaldehyde. The latter compound was found to possess high antiulcer activity.

引用

页码：1712 / 1718

页数：7

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