Current and novel polymeric biomaterials for neural tissue engineering

被引:289
作者
Boni, Rossana [1 ]
Ali, Azam [1 ]
Shavandi, Amin [1 ,4 ]
Clarkson, Andrew N. [2 ,3 ]
机构
[1] Univ Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New Zealand
[2] Univ Otago, Brain Hlth Res Ctr, Dept Anat, POB 56, Dunedin 9054, New Zealand
[3] Univ Otago, Brain Res New Zealand, POB 56, Dunedin 9054, New Zealand
[4] Univ Libre Bruxelles, BioMatter Biomass Transformat Lab BTL, Ecole Polytech Bruxelles, EIB, Ave FD Roosevelt 50,CP 165-61, B-1050 Brussels, Belgium
关键词
Biomaterials; Synthetic and natural polymers; Neural tissue engineering; Axonal regeneration; Neuronal differentiation; PERIPHERAL-NERVE REGENERATION; HYALURONIC-ACID HYDROGELS; LOADED CHITOSAN NANOPARTICLES; MAGNETICALLY ALIGNED COLLAGEN; CILIARY NEUROTROPHIC FACTOR; STEM-CELL DIFFERENTIATION; SPINAL-CORD; DRUG-DELIVERY; CARBON NANOTUBES; EXTRACELLULAR-MATRIX;
D O I
10.1186/s12929-018-0491-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The nervous system is a crucial component of the body and damages to this system, either by of injury or disease, can result in serious or potentially lethal consequences. Restoring the damaged nervous system is a great challenge due to the complex physiology system and limited regenerative capacity.Polymers, either synthetic or natural in origin, have been extensively evaluated as a solution for restoring functions in damaged neural tissues. Polymers offer a wide range of versatility, in particular regarding shape and mechanical characteristics, and their biocompatibility is unmatched by other biomaterials, such as metals and ceramics. Several studies have shown that polymers can be shaped into suitable support structures, including nerve conduits, scaffolds, and electrospun matrices, capable of improving the regeneration of damaged neural tissues. In general, natural polymers offer the advantage of better biocompatibility and bioactivity, while synthetic or non-natural polymers have better mechanical properties and structural stability. Often, combinations of the two allow for the development of polymeric conduits able to mimic the native physiological environment of healthy neural tissues and, consequently, regulate cell behaviour and support the regeneration of injured nervous tissues.Currently, most of neural tissue engineering applications are in pre-clinical study, in particular for use in the central nervous system, however collagen polymer conduits aimed at regeneration of peripheral nerves have already been successfully tested in clinical trials.This review highlights different types of natural and synthetic polymers used in neural tissue engineering and their advantages and disadvantages for neural regeneration.
引用
收藏
页数:21
相关论文
共 221 条
[1]   Peripheral nerve injuries: Long term follow-up results of rehabilitation [J].
Adiguzel, Emre ;
Yasar, Evren ;
Tecer, Duygu ;
Guzelkucuk, Umut ;
Taskaynatan, Mehmet Ali ;
Kesikburun, Serdar ;
Ozgul, Ahmet .
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION, 2016, 29 (02) :367-371
[2]   Hydrogel: Preparation, characterization, and applications: A review [J].
Ahmed, Enas M. .
JOURNAL OF ADVANCED RESEARCH, 2015, 6 (02) :105-121
[3]   Polymeric Scaffolds in Neural Tissue Engineering: A Review [J].
Ai, Jafar ;
Kiasat-Dolatabadi, Anahita ;
Ebrahimi-Barough, Somayeh ;
Ai, Armin ;
Lotfibakhshaiesh, Nasrin ;
Norouzi-Javidan, Abbas ;
Saberi, Hooshang ;
Arjmand, Babak ;
Aghayan, Hamid Reza .
ARCHIVES OF NEUROSCIENCE, 2014, 1 (01)
[4]   Rolled graphene oxide foams as three-dimensional scaffolds for growth of neural fibers using electrical stimulation of stem cells [J].
Akhavan, Omid ;
Ghaderi, Elham ;
Shirazian, Soheil A. ;
Rahighi, Reza .
CARBON, 2016, 97 :71-77
[5]   Near infrared laser stimulation of human neural stem cells into neurons on graphene nanomesh semiconductors [J].
Akhavan, Omid ;
Ghaderi, Elham ;
Shirazian, Soheil A. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 126 :313-321
[6]   The use of graphene in the self-organized differentiation of human neural stem cells into neurons under pulsed laser stimulation [J].
Akhavan, Omid ;
Ghaderi, Elham .
JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (34) :5602-5611
[7]   Differentiation of human neural stem cells into neural networks on graphene nanogrids [J].
Akhavan, Omid ;
Ghaderi, Elham .
JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (45) :6291-6301
[8]   Flash photo stimulation of human neural stem cells on graphene/TiO2 heterojunction for differentiation into neurons [J].
Akhavan, Omid ;
Ghaderi, Elham .
NANOSCALE, 2013, 5 (21) :10316-10326
[9]   In Vivo Electrochemical Analysis of a PEDOT/MWCNT Neural Electrode Coating [J].
Alba, Nicolas A. ;
Du, Zhanhong J. ;
Catt, Kasey A. ;
Kozai, Takashi D. Y. ;
Cui, X. Tracy .
BIOSENSORS-BASEL, 2015, 5 (04) :618-646
[10]   Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering [J].
Alhosseini, Sanaz Naghavi ;
Moztarzadeh, Fathollah ;
Mozafari, Masoud ;
Asgari, Shadnaz ;
Dodel, Masumeh ;
Samadikuchaksaraei, Ali ;
Kargozar, Saeid ;
Jalali, Newsha .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :25-34