The role of blood transfusions and iron intake on retinopathy of prematurity

Background: The role of blood transfusions and iron intake in the pathogenesis or retinopathy of prematurity (ROP) is controversial. Aim: To evaluate the influence of packed red cell (PRC) transfusions and iron intake on ROP incidence. Study design: Prospective observational study. Subjects: Forty-five preterm infants with birthweight <1250 g were studied. After ophthalmological study, they were divided into group A (n = 24) that included newborns without ROP, and group B (n = 21) that included newborns with ROP. Results: Logistic regression analysis demonstrated that gestational age (OR 0.61; 95% C.I. 0.41-0.90), transfusion volume during the first week (OR 1.16; 95% C.I. 1.03-1.3) and during the first 2 months of life (OR 2.93; 95% C.I. 1.52-5.62), and iron intake during the first week of life (OR 1.15; C.I. 1.01-1.32) and during the first 2 months of life (OR 2.93; 95% C.I. 1.52-5.62) were associated with the development of ROP. Conclusion: Our study showed that gestational age, blood transfusion volume and iron load by transfusions are associated with the risk of occurrence of ROP in infants with a birthweight of less than 1250 g. <(c)> 2001 Elsevier Science Ireland Ltd. All rights reserved.