Future Antithrombotic Therapies in Cardiology

被引：2
作者：
Baeuml, Marina [1 ]
Hilgendorf, Ingo [1 ]
机构：
[1] Univ Freiburg, Univ Heart Ctr Freiburg Bad Krozingen, Fac Med, Dept Cardiol & Angiol 1, Hugstetter St 55, D-79106 Freiburg, Germany
来源：
HAMOSTASEOLOGIE | 2018年 / 38卷 / 04期
关键词：
thrombus; platelets; therapy; GLYCOPROTEIN-VI; GPVI-FC; COAGULATION; PLATELETS; ANTICOAGULANTS; CLOPIDOGREL; PLASMA; SINGLE;
D O I：
10.1055/s-0038-1670653
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thrombi are composed of activated platelets and fibrin, the latter being the final product of the blood coagulation system. Therefore, antithrombotic therapies may either interfere with adhesion, aggregation, secretion or signalling of platelets or with fibrin formation. Established drugs potently inhibit clot formation, but also increase the risk of bleeding. In this review article, we discuss novel strategies for the inhibition of pathological thrombosis while enabling normal haemostasis, thus minimizing the risk of bleeding.
引用
收藏
页码：236 / 239
页数：4
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