Effects of non-viable Lactobacillus reuteri combining with 14-day standard triple therapy on Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial

被引：55

作者：

Yang, Chenghai ^{[1
]}

Liang, Liping ^{[1
]}

Lv, Pinjing ^{[1
]}

Liu, Le ^{[1
]}

Wang, Siqi ^{[1
]}

Wang, Zhiqing ^{[1
]}

Chen, Ye ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, State Key Lab Organ Failure Res, Guangdong Prov Key Lab Gastroenterol,Dept Gastroe, 1838 North Guangzhou Ave, Guangzhou 510515, Peoples R China

来源：

HELICOBACTER | 2021年 / 26卷 / 06期

关键词：

gut microbiota; Helicobacter pylori; Lactobacillus reuteri; randomized controlled trial; triple therapy; IRRITABLE-BOWEL-SYNDROME; GUT MICROBIOTA; GEN; NOV; PROBIOTICS; INFECTION; MULTICENTER; INHIBITION; MANAGEMENT; RESISTANCE; BINDING;

D O I：

10.1111/hel.12856

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Viable probiotics have shown effects on the eradication of Helicobacter pylori, but the role of non-viable probiotics in H. pylori eradication is unclear. This study aimed to evaluate the effects of non-viable Lactobacillus reuteri DSM17648 combining with 14-day standard triple therapy on H. pylori eradication. Materials and Methods Two hundred treatment-naive H. pylori-positive adult patients were randomized equally to receive non-viable L. reuteri DSM17648 (LR group) or placebo for 4 weeks, with the latter 2 weeks treated together with triple therapy. The Gastrointestinal Symptom Rating Scale (GSRS) was completed before and after treatment. Stool samples were collected for 16S rRNA gene sequencing at week0, week2, and week8. Results Eradication rates in the LR group and the placebo group were 81.8% and 83.7% in ITT analysis (p = 0.730), 86.2% and 87.2% in PP analysis (p = 0.830), respectively. After treatment, the mean GSRS score decreased significantly in the LR group as compared with the placebo group (1.9 +/- 0.2 vs. 2.7 +/- 0.3; p = 0.030). Significantly less patients in the LR group as compared with the placebo group reported abdominal distention (5.1% vs. 16.3%; p = 0.010) and diarrhea (11.1% vs. 23.5%; p = 0.022). The relative abundance of Proteobacteria phylum and Escherichia-Shigella genus in the placebo group was about 4.0-fold and 8.1-fold of that in the LR group at wk2, respectively. Significant changes of diversity and enhancements of Fusicatenibacter, Subdoligranulum, and Faecalibacterium were observed in the LR group compared with the placebo group. Conclusions Supplementation of non-viable L. reuteri DSM17648 with triple therapy did not improve the eradication rate of H. pylori, but it helped to build up a beneficial microbial profile and reduced the frequencies of abdominal distention, diarrhea, and the GSRS score.

引用

页数：10

共 54 条

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