Self emulsifying drug delivery system for enhanced solubility and dissolution of glipizide

被引：78

作者：

Agrawal, Anuj G. ^{[1
]}

Kumar, Ashok ^{[1
]}

Gide, Paraag S. ^{[2
]}

机构：

[1] Cachet Pharmaceut Pvt Ltd, ALKEM Grp, Baddi 173205, Solon, India

[2] Dr LH Hiranandani Coll Pharm, Ulhasnagar 421003, Thane, India

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2015年 / 126卷

关键词：

Self emulsifying drug delivery system; Glipizide; Poorly water-soluble drug; Surfactant; Bioavailability; WATER-SOLUBLE DRUG; LIPID-BASED FORMULATIONS; IN-VIVO EVALUATION; ORAL BIOAVAILABILITY; LIPOPHILIC DRUGS; SNEDDS; DESIGN; VITRO; NANOPARTICLES; RATS;

D O I：

10.1016/j.colsurfb.2014.11.022

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The aim of this study was to develop self emulsifying drug delivery systems (SEDDS) of glipizide and to convert it into solid SEDDS (S-SEDDS) using Syloid (R) 244 FP as adsorbent. Solubility study, ternary phase diagram, robustness to dilution, thermodynamic stability study and globule size analysis were adopted to optimize liquid SEDDS. S-SEDDS were evaluated for various studies including in vivo study. The optimized liquid SEDDS formulation consisted of phosphatidylcholine, Tween 80 and Transcutol P as oil, surfactant and cosolvent. In vivo study demonstrated that blood glucose levels were efficiently controlled with S-SEDDS compared with pure drug. The results of this study suggest the potential use of developed S-SEDDS formulation for the delivery of poorly water-soluble drug glipizide. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：553 / 560

页数：8

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